Medical history, drug exposure and the risk of psoriasis
Medical history, drug exposure and the risk of psoriasis
复制标题
DOI：
10.1159/000111509
复制
发表时间：
2008-01-01
期刊：
影响因子：
3.4
通讯作者：
Parazzini, Fabio
中科院分区：
文献类型：
--
作者：
Naldi, Luigi;Chatenoud, Liliane;Parazzini, Fabio
背景/目的：评估银屑病与选定的医疗条件和诊断前使用的一些药物的相关性。方法：采用多中心病例对照研究方法，对20所综合医院和教学医院的门诊病例进行研究。病例的入选标准是皮肤科医生首次诊断为银屑病，并且在报告疾病发作后不超过2年的皮肤表现史。对照组是在与病例相同的中心随机选择的第一批符合条件的皮肤病患者。共招募了560例病例和690例对照。结果如下：高血压患者银屑病的优势比（OR）为0.8（95%CI，0.5-1.3），糖尿病患者为1.1（95%CI 0.6-2.0），高血压患者为1.1（95%CI 0.7-1.7）。组胺2受体拮抗剂暴露与银屑病呈负相关：OR 0.3（95% CI 0.1-0.8）。结论：我们的研究排除了银屑病在首次诊断时与常见慢性疾病的强相关性。报告的银屑病与相对常见的疾病（如糖尿病、高血压和高脂血症）的相关性可能代表了众所周知的银屑病风险因素（如吸烟和超重）的晚期效应，或反映了与银屑病本身的长期病程相关的因素。版权所有（c）2008 S. Karger AG，巴塞尔。
Background/Aims: To evaluate the association of psoriasis with selected medical conditions and a number of drugs used before diagnosis. Methods: Multicenter case-control study involving outpatient services of 20 general and teaching hospitals. Entry criteria for cases were a first diagnosis of psoriasis made by a dermatologist and a history of skin manifestations of no more than 2 years after the reported onset of the disease. Controls were the first eligible dermatological patients observed on randomly selected days in the same centers as cases. A total of 560 cases and 690 controls were recruited. Results: The odds ratio ( OR) of psoriasis was 0.8 (95% confidence interval, CI, 0.5-1.3) in hypertensive subjects, 1.1 (95% CI 0.6-2.0) in diabetics and 1.1 (95% CI 0.7-1.7) in hyperlipidemic subjects. Histamine 2 receptor antagonist exposure was negatively associated with psoriasis: OR 0.3 (95% CI 0.1-0.8). Conclusion: Our study rules out a strong association of psoriasis at its first ever diagnosis with common chronic conditions. The reported associations of psoriasis with relatively common conditions such as diabetes mellitus, hypertension and hyperlipidemia may represent a late effect of well-known risk factors for psoriasis such as smoking and overweight or reflect factors related to the long course of psoriasis itself. Copyright (c) 2008 S. Karger AG, Basel.