Activity in fusiform face area modulated as a function of working memory load
Activity in fusiform face area modulated as a function of working memory load
复制标题
DOI：
10.1016/s0926-6410(00)00056-2
复制
发表时间：
2001-01-01
期刊：
影响因子：
--
通讯作者：
D'Esposito, M
中科院分区：
文献类型：
--
作者：
Druzgal, TJ;D'Esposito, M
先前的功能性磁共振成像（fMRI）结果表明，纹外视觉区域在知觉加工中起主要作用，而前额叶皮质（PFC）在工作记忆中起主要作用。相比之下，对猴子进行的单细胞记录研究表明纹外视觉区域与视觉工作记忆任务之间存在关联。在本研究中，我们测试了对于灰度面部的n - back任务，PFC和梭状回面孔区（FFA）的活动是否会随着任务需求的增加而改变。由于不同条件下的刺激呈现是相同的，n - back任务使我们能够在保持知觉和运动需求不变的情况下，参数化地改变不同条件下的工作记忆需求。本研究重复了PFC激活区域的结果，即其随着任务负载n的增加而直接增加。在所有受试者中的新发现是FFA的激活也随着任务负载n的增加而直接增加。由于在三种任务条件下知觉需求是相同的，这些发现表明PFC和FFA的活动都随着面部工作记忆需求而变化。（C）2001年爱思唯尔科学出版社。版权所有。
Previous fMRI results suggest that extrastriate visual areas have a predominant role in perceptual processing while the prefrontal cortex (PFC) has a predominant role in working memory. In contrast, single-unit recording studies in monkeys have demonstrated a relationship between extrastriate visual areas and visual working memory tasks. In this study we tested whether activity in both the PFC and fusiform Face area (FFA) changed with increasing demands of an n-back task for gray-scale faces, Since stimulus presentation was identical across conditions, the n-back task allowed us to parametrically vary working memory demands across conditions while holding perceptual and motor demands constant. This study replicated the result of PFC areas of activation that increased directly with load n of the task. The novel finding in all subjects was FFA activation that also increased directly with load n of the task. Since perceptual demands were equivalent across the three task conditions, these findings suggest that activity in both the PFC and the FFA vary with face working memory demands. (C) 2001 Elsevier Science B.V. All rights reserved.