The free-radical damage theory: Accumulating evidence against a simple link of oxidative stress to ageing and lifespan
The free-radical damage theory: Accumulating evidence against a simple link of oxidative stress to ageing and lifespan
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DOI：
10.1002/bies.201000132
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发表时间：
2011-04-01
期刊：
影响因子：
4
通讯作者：
Selman, Colin
中科院分区：
文献类型：
--
作者：
Speakman, John R.;Selman, Colin
最近对一种小型欧洲洞穴蝾螈（Proteus anguinus）的研究表明，它具有非凡的寿命，但它似乎对氧化损伤具有普通的防御能力。这篇论文是在一系列其他研究的结尾，这些研究对衰老的自由基损伤理论提出了质疑。这一理论在20世纪90年代成为解释我们为什么会衰老和死亡的主导理论。尽管有大量相关证据支持它，但过去五年的研究对其重要性提出了质疑。特别是，这些研究包括对主要抗氧化剂基因敲除（单独和联合敲除）的小鼠的研究，这些研究显示氧化损伤的预期增加，但对寿命没有影响。结合起来，这些发现提出了一个根本性的问题，即自由基损伤理论是否仍然有助于理解衰老过程，以及寿命和生活史的变化。
Recent work on a small European cave salamander (Proteus anguinus) has revealed that it has exceptional longevity, yet it appears to have unexceptional defences against oxidative damage. This paper comes at the end of a string of other studies that are calling into question the free-radical damage theory of ageing. This theory rose to prominence in the 1990s as the dominant theory for why we age and die. Despite substantial correlative evidence to support it, studies in the last five years have raised doubts over its importance. In particular, these include studies of mice with the major antioxidant genes knocked out (both singly and in combination), which show the expected elevation in oxidative damage but no impact on lifespan. Combined, these findings raise fundamental questions over whether the free-radical damage theory remains useful for understanding the ageing process, and variation in lifespan and life histories.