Effect of short-term lycopene supplementation and postprandial dyslipidemia on plasma antioxidants and biomarkers of endothelial health in young, healthy individuals.
Effect of short-term lycopene supplementation and postprandial dyslipidemia on plasma antioxidants and biomarkers of endothelial health in young, healthy individuals.
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在年轻，健康个体中，短期补充番茄红素补充和餐后血脂异常对内皮健康的血浆抗氧化剂和生物标志物的影响。
DOI：
10.2147/vhrm.2008.04.01.213
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发表时间：
2008
影响因子：
2.9
通讯作者：
Hughson RL
中科院分区：
文献类型：
--
作者：
Denniss SG;Haffner TD;Kroetsch JT;Davidson SR;Rush JW;Hughson RL
本研究的目的是检验以下假设：在年轻健康受试者中，短期补充番茄红素会减弱高脂餐（HFm）对血浆脂溶性抗氧化剂和血管氧化应激和炎症生物标志物的影响。在限制含甘草酸的食物1周（LYr）后，在N = 18名23 ± 2岁的男性中在空腹状态下和HFm和低脂餐（LFm）后3小时采集血液，在N = 9名23 ± 1岁的女性中仅在HFm后采集血液。在持续饮食LYr下，在80 mg/天番茄红素补充（LYs）1周后，还在餐前和餐后采集血液。在禁食状态下，与LYr相比，LYs不仅诱发血浆番茄红素增加>2倍，而且还增加血浆β-胡萝卜素和α-生育酚（p < 0.01），尽管LYs不影响血浆硝酸盐/亚硝酸盐（一氧化氮的生物标志物）、丙二醛（脂质氧化应激的生物标志物）、血管和细胞间粘附分子或C-反应蛋白（炎症的生物标志物）。与假设相反，HFm诱导的血脂异常状态并不影响血浆丙二醛，C-反应蛋白，或粘附分子在LYr或LYs。HFm和LFm均与一氧化氮代谢产物硝酸盐/亚硝酸盐和脂溶性抗氧化剂的减少相关（p < 0.05）。数据显示，1周的LYs增加了血浆番茄红素、β-胡萝卜素和α-生育酚，尽管血浆脂溶性抗氧化剂库发生了这些显著变化，但在空腹状态下以及在年轻健康受试者中由HFm诱导的血脂异常期间，血管氧化应激和炎症的生物标志物不受影响。
The objective of this study was to test the hypothesis that the effect of a high-fat meal (HFm) on plasma lipid-soluble antioxidants and biomarkers of vascular oxidative stress and inflammation would be attenuated by short-term lycopene supplementation in young healthy subjects. Following restriction of lycopene-containing foods for 1-wk (LYr), blood was collected in a fasting state and 3 h after a HFm and a low-fat meal (LFm) in N = 18 men aged 23 ± 2 years, and after a HFm only in N = 9 women aged 23 ± 1 years. Blood was also sampled pre- and post-meals following 1-wk of 80 mg/day lycopene supplementation (LYs) under continued dietary LYr. In the fasting state, LYs compared with LYr not only evoked a >2-fold increase in plasma lycopene but also increased plasma β-carotene and α-tocopherol (p < 0.01), though LYs did not affect plasma nitrate/nitrite (biomarker of nitric oxide), malondialdehyde (biomarker of lipid oxidative stress), vascular- and intercellular-adhesion molecules or C-reactive protein (biomarkers of inflammation). Contrary to the hypothesis, the HFm-induced dyslipidemic state did not affect plasma malondialdehyde, C-reactive protein, or adhesion molecules in either LYr or LYs. Both the HFm and LFm were associated with decreases in the nitric oxide metabolites nitrate/nitrite and lipid-soluble antioxidants (p < 0.05). The data revealed that 1-wk of LYs increased plasma lycopene, β-carotene, and α-tocopherol yet despite these marked changes to the plasma lipid-soluble antioxidant pool, biomarkers of vascular oxidative stress and inflammation were unaffected in the fasted state as well as during dyslipidemia induced by a HFm in young healthy subjects.