Experience with milk and an artificial nipple promotes conditioned opioid activity in the rat fetus.
Experience with milk and an artificial nipple promotes conditioned opioid activity in the rat fetus.
复制标题
牛奶和人工乳头的体验促进了大鼠胎儿的条件性阿片类药物活性。
DOI：
10.1002/dev.420260702
复制
发表时间：
1993
影响因子：
2.2
通讯作者：
Smotherman,WP
中科院分区：
文献类型：
--
作者：
Robinson,SR;Arnold,HM;Spear,NE;Smotherman,WP
在皮肤敏感性的行为生物测定中，牛奶促进大鼠胎儿kappa阿片系统的活性并降低反应性。在这项研究中，E20大鼠胎儿提供了一个人工乳头（CS）和口内输注牛奶（US），以调节阿片类药物的活性。CS和US的成对呈现导致口周皮肤敏感性的条件性变化，这在单独暴露于CS、单独暴露于US或US和CS的明确不成对呈现的组中不明显。选择性阿片类拮抗剂之间的调节和测试表明，再次暴露于乳头导致内源性阿片系统的激活。乳头促进了μ阿片受体的活性，而不是κ阿片受体的活性。条件阿片活性的人工乳头在胎儿中，缺乏经验的牛奶或其他吸吮刺激，意味着条件的变化，内源性阿片系统的新生大鼠可能会迅速发展在第一次吸吮事件。©约翰威利父子公司
Milk promotes activity in the kappa opioid system of the rat fetus and reduced responsiveness in a behavioral bioassay of cutaneous sensitivity. In the study, E20 rat fetuses were presented with an artificial nipple (CS) and intraoral infusions of milk (US) to condition opioid activity. Paired presentations of the CS and US resulted in conditioned changes in perioral cutaneous sensitivity, which was not evident in groups exposed to the CS alone, US alone, or explicitly unpaired presentations of US and CS. Selective opioid antagonists administered between conditioning and testing revealed that reexposure to the nipple resulted in activation of the endogenous opiod system. The nipple promoted activity at mu, not kappa, opioid receptos. Conditioned opioid activity to an artificial nipple in the fetus, which lacks experience with milk or other suckling stimuli, implies that conditioned changes in the endogeneous opioid system of the newborn rat may develop quickly during the first suckling episodes. © John Wiley & Sons, Inc.