Regulation of B versus T lymphoid lineage fate decision by the proto-oncogene LRF
Regulation of B versus T lymphoid lineage fate decision by the proto-oncogene LRF
复制标题
DOI：
10.1126/science.1140881
复制
发表时间：
2007-05-11
期刊：
影响因子：
56.9
通讯作者：
Pandolfi, Pier Paolo
中科院分区：
文献类型：
--
作者：
Maeda, Takahiro;Merghoub, Taha;Pandolfi, Pier Paolo
骨髓中的造血干细胞产生淋巴祖细胞，随后分化为 B 和 T 淋巴细胞。在这里，我们证明原癌基因 LRF 在 B 淋巴细胞与 T 淋巴细胞的命运决定中发挥着重要作用。我们证明，LRF 通过抑制细胞命运信号蛋白 Notch 产生的 T 细胞指示信号，是指导小鼠早期淋巴祖细胞发育成 B 谱系细胞的关键。我们提出了一种淋巴谱系定型的新模型，其中 LRF 充当细胞决定 B 与 T 谱系的主要调节因子。
Hematopoietic stem cells in the bone marrow give rise to lymphoid progenitors, which subsequently differentiate into B and T lymphocytes. Here we show that the proto-oncogene LRF plays an essential role in the B versus T lymphoid cell-fate decision. We demonstrate that LRF is key for instructing early lymphoid progenitors in mice to develop into B lineage cells by repressing T cell-instructive signals produced by the cell-fate signal protein, Notch. We propose a new model for lymphoid lineage commitment, in which LRF acts as a master regulator of the cell's determination of B versus T lineage.