The first asymmetric Sonogashira coupling for the enantioselective generation of planar chirality in paracyclophanes.
The first asymmetric Sonogashira coupling for the enantioselective generation of planar chirality in paracyclophanes.
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DOI：
10.1039/b818904h
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发表时间：
2009-04
影响因子：
4.9
通讯作者：
Kazumasa Kanda;T. Koike;K. Endo;T. Shibata
中科院分区：
文献类型：
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作者：
Kazumasa Kanda;T. Koike;K. Endo;T. Shibata
二碘代对环芳与炔的双Sonogashira偶联反应得到了平面手性二炔基对环芳，由PdCl（2）（CH（3）CN）（2）和Taniaphos原位制备的手性Pd催化剂实现了第一次不对称Sonogashira偶联反应，反应速率高达约. 80% ee。
The double Sonogashira coupling of diiodoparacyclophanes with alkynes proceeded to give planarly chiral dialkynylparacyclophanes; a chiral Pd catalyst, which was prepared in situ from PdCl(2)(CH(3)CN)(2) and Taniaphos, realized the first asymmetric Sonogashira coupling with up to ca. 80% ee.