Nucleoside derivatives from the marine-derived fungus Aspergillus versicolor
Nucleoside derivatives from the marine-derived fungus Aspergillus versicolor
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来自海洋源性真菌花色曲霉的核苷衍生物。
DOI：
10.1080/14786419.2014.891114
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发表时间：
2014-06-18
影响因子：
2.2
通讯作者：
Wang, Chang-Yun
中科院分区：
文献类型：
--
作者：
Chen, Min;Fu, Xiu-Mei;Wang, Chang-Yun
从南海柳珊瑚（Dichotella gemmacea）中分离得到4个核苷衍生物（1 ~ 4个）。采用核磁共振和质谱综合分析方法对其结构进行了鉴定。对分离得到的代谢物进行了细胞毒性、抗菌活性和对盐渍对虾的致死性评价。化合物1/2对表皮葡萄球菌具有选择性抗菌活性，MIC值为12.5M。值得注意的是，结构在SciFinder Scholar中列出的1和2没有相关的参考文献。这是关于它们的分离、结构解析和生物活性的首次报道。
Four nucleoside derivatives (1-4) were isolated from the fungus Aspergillus versicolor derived from the gorgonian Dichotella gemmacea collected in the South China Sea. Their structures were elucidated by comprehensive spectroscopic method of NMR and MS analysis. All isolated metabolites were evaluated for their cytotoxicity, antibacterial activity and lethality towards brine shrimp Artemia salina. Compounds 1/2 exhibited selective antibacterial activity against Staphylococcus epidermidis with an MIC value of 12.5M. It should be noted that 1 and 2, whose structures were listed in SciFinder Scholar, had no associated reference. This is the first report about their isolation, structure elucidation and biological activities.