INCREASES IN PLATELET AND RED-CELL COUNTS, BLOOD-VISCOSITY, AND ARTERIAL-PRESSURE DURING MILD SURFACE COOLING - FACTORS IN MORTALITY FROM CORONARY AND CEREBRAL THROMBOSIS IN WINTER
INCREASES IN PLATELET AND RED-CELL COUNTS, BLOOD-VISCOSITY, AND ARTERIAL-PRESSURE DURING MILD SURFACE COOLING - FACTORS IN MORTALITY FROM CORONARY AND CEREBRAL THROMBOSIS IN WINTER
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DOI：
10.1136/bmj.289.6456.1405
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发表时间：
1984-01-01
影响因子：
105.7
通讯作者：
CHELLIAH, R
中科院分区：
文献类型：
--
作者：
KEATINGE, WR;COLESHAW, SRK;CHELLIAH, R
人类受试者在24 °的流动空气中暴露于6小时的温和表面冷却。核心温度几乎没有下降（0.4 ℃）。C）使红细胞压积增加7%，并增加血小板计数，通常是平均血小板体积，使血小板占血浆体积的比例增加15%。这些增加很少发生在第1 h。全血粘度增加21%;血浆粘度通常增加，动脉压平均从126/69上升至138/87 mm Hg。血浆胆固醇浓度升高，高密度脂蛋白和低密度脂蛋白组分中，总脂蛋白和脂蛋白组分的购买值不变。血小板，红细胞和粘度的增加与正常的体温调节温和的表面冷却提供了一个可能的解释冠状动脉和脑血栓在寒冷的天气迅速增加。升高的动脉压和可能的胆固醇浓度可能导致血栓形成增加的缓慢成分。
Exposure of human subjects to 6 h of mild surface cooling in moving air at 24.degree. C with little fall in core temperature (0.4.degree. C) increased the packed cell volume by 7% and increased the platelet count and usually the mean platelet volume to produce a 15% increase in the fraction of plasma volume occupied by platelets. Little of these increases occurred in the 1st h. Whole blood viscosity increased by 21%; plasma viscosity usually increased and arterial pressure rose on average from 126/69 to 138/87 mm Hg. Plasma cholesterol concentration increased, in boyh high and low density lipoprotein fractions, buy values of total lipoprotein and lipoprotein fractions were unchanged. The increases in platelets, red cells and viscosity associated with normal thermoregulatory adjustments to mild surface cooling provide a probable explanation for rapid increases in coronary and cerebral thrombosis in cold weather. The raised arterial pressure and possibly cholesterol concentration may contribute to slower components of the increased thrombosis.