200 Kd neurofilament protein binds Al, Cu and Zn.
200 Kd neurofilament protein binds Al, Cu and Zn.
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200 Kd 神经丝蛋白结合 Al、Cu 和 Zn。
DOI：
10.1016/s0006-291x(88)80080-9
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发表时间：
1988
影响因子：
3.1
通讯作者：
Evenson,MA
中科院分区：
文献类型：
--
作者：
Pierson,KB;Evenson,MA
从脊髓中分离200 Kd的人和牛神经丝蛋白并纯化至均一。纯化的蛋白质被证明是金属结合蛋白，其结合至少一摩尔的Al，一摩尔的Cu和四摩尔的Zn。无论是去磷酸化的蛋白质，也不是平衡透析对25 mM EDTA，pH 7.0，除去这些金属。这是第一个报告的人类蛋白质的化学计量结合铝。
200 Kd human and bovine neurofilament proteins were isolated from spinal cord and purified to homogeneity. The purified proteins were shown to be metal-binding proteins which bind at least one mole of Al, one mole of Cu and four moles of Zn. Neither dephosphorylation of the protein nor equilibrium dialysis against 25 mM EDTA, pH 7.0, removed these metals. This is the first report of a human protein which stoichiometrically binds Al.