Role of microRNA-146a in normal and malignant hematopoietic stem cell function.
Role of microRNA-146a in normal and malignant hematopoietic stem cell function.
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DOI：
10.3389/fgene.2014.00219
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发表时间：
2014
影响因子：
3.7
通讯作者：
Starczynowski DT
中科院分区：
文献类型：
--
作者：
Zhao JL;Starczynowski DT
造血的调控是由microRNAs（miRNAs）控制的。本文就miR-146 a及其在正常和恶性造血中的作用作一综述。miR-146 a是通过抑制两个靶点TRAF 6和IRAK 1来激活免疫细胞的负调节因子。miR-146 a的基因缺失证实了miR-146 a在先天免疫信号传导以及造血干细胞功能中的作用。miR-146 a还涉及人骨髓增生异常综合征（MDS）的发病机制，因为它位于5号染色体上的通常缺失区域内，并且miR-146 a缺陷小鼠表现出MDS样疾病的特征。通过遗传和表达分析对miR-146 a有了新的认识，我们强调并讨论了miR-146 a在稳态和炎症过程中生理造血以及MDS中的最新进展。
Regulation of hematopoiesis is controlled by microRNAs (miRNAs). In this review, we focus on miR-146a, and its role in regulating normal and malignant hematopoiesis. miR-146a is a negative regulator of immune cell activation by repressing two targets, TRAF6 and IRAK1. Genetic deletion of miR-146a confirmed a role of miR-146a during innate immune signaling as well as for hematopoietic stem cell function. miR-146a is also implicated in the pathogenesis of human myelodysplastic syndromes (MDSs) as it is located within a commonly deleted region on chromosome 5, and miR-146a-deficient mice exhibit features of an MDS-like disease. With new insight into miR-146a through genetic and expression analyses, we highlight and discuss the recent advances in the understanding of miR-146a in physiological hematopoiesis during steady-state and inflammation, as well as in MDS.