Meta-analysis of the effect of β-glucan intake on blood cholesterol and glucose levels
Meta-analysis of the effect of β-glucan intake on blood cholesterol and glucose levels
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DOI：
10.1016/j.nut.2010.11.006
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发表时间：
2011-10-01
期刊：
影响因子：
4.4
通讯作者：
Cummins, Enda
中科院分区：
文献类型：
--
作者：
Tiwari, Uma;Cummins, Enda
目的：对流行病学研究进行荟萃分析，以评估燕麦和大麦的 β-葡聚糖摄入量与人类血液胆固醇水平、甘油三酯/三酰甘油 (TGL/TAG) 水平和血糖水平 (BGL) 之间的关系。此外，将β-葡聚糖对总胆固醇（TC）和BGL的影响转化为经验剂量反应模型。方法：分析了30篇评估不同暴露水平的β-葡聚糖对血液胆固醇和BGL影响的研究文章，得出126项临床研究。结果：TC存在显着的负相关（-0.60 mmol/L，95%置信区间[Cl]-0.85至-0.34），消耗β-葡聚糖后，低密度脂蛋白（-0.66 mmol/L，95% Cl -0.96 至 -0.36）和 TGL/TAG（-0.04 mmol/L，95% Cl -0.15 至 0.07）。相比之下，随机效应模型发现高密度脂蛋白胆固醇增加（0.03 mmol/L，95% Cl -0.06 至 0.13）。分析显示，BGL（-2.58 mmol/L，95% Cl -3.22 至 -1.84）存在显着变化，研究之间（I-2 = 97%）和研究间（tau(2) = 5.88）具有高度异质性。固定效应模型显示TC、低密度脂蛋白和BGL有显着变化，而高密度脂蛋白和TGL/TAG没有显着变化。剂量反应模型显示，每天摄入3g/d的燕麦或大麦β-葡聚糖足以降低TC。结论：摄入3g/d的燕麦或大麦β-葡聚糖足以降低血液胆固醇，但对BGL的影响尚无定论，异质性较高，需要进一步的临床研究和较长的干预周期。 (C) 2011 Elsevier Inc. 保留所有权利。
Objective: A meta-analysis was performed on epidemiologic studies to assess the relation between beta-glucan consumption from oats and from barley on blood cholesterol level, triglyceride/triacylglycerol (TGL/TAG) level, and blood glucose level (BGL) in humans. In addition, the effect of beta-glucan on total cholesterol (TC) and BGL was translated into an empirical dose-response model.Methods: Thirty research articles that evaluated the effect of different exposure levels of beta-glucan on blood cholesterol and BGL were analyzed, yielding 126 clinical studies.Results: There was a significant inverse relation in TC (-0.60 mmol/L, 95% confidence interval [Cl] -0.85 to -0.34), low-density lipoprotein (-0.66 mmol/L, 95% Cl -0.96 to -0.36), and TGL/TAG (-0.04 mmol/L, 95% Cl -0.15 to 0.07) after consumption of beta-glucan. In contrast, an increase in high-density lipoprotein cholesterol was noted (0.03 mmol/L, 95% Cl -0.06 to 0.13) with the random-effect model. The analysis showed a significant change in BGL (-2.58 mmol/L, 95% Cl -3.22 to -1.84) with high heterogeneity between (I-2 = 97%) and across (tau(2) = 5.88) the studies. The fixed-effect model showed a significant change in TC, low-density lipoprotein, and BGL, whereas it showed no significant changes in high-density lipoprotein and TGL/TAG. The dose-response model showed that a 3-g/d dose of oat or barley beta-glucan was sufficient to decrease TC.Conclusion: Consumption of 3 g/d of oat or barley beta-glucan is sufficient to decrease blood cholesterol, whereas the effect on BGL is still inconclusive, with high heterogeneity, and requires further clinical research studies with longer intervention periods. (C) 2011 Elsevier Inc. All rights reserved.