Downregulation of hnRNP C1/C2 by siRNA sensitizes HeLa cells to various stresses
Downregulation of hnRNP C1/C2 by siRNA sensitizes HeLa cells to various stresses
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DOI：
10.1007/s11010-006-9308-2
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发表时间：
2007-02-01
影响因子：
4.3
通讯作者：
Ayusawa, Dai
中科院分区：
文献类型：
--
作者：
Hossain, Mohammad Nazir;Fuji, Michihiko;Ayusawa, Dai
The heterogeneous nuclear ribonucleoprotein C1/C2 is one of the most abundant proteins in the nucleus, and shown to have roles in cellular differentiation and proliferation through post-transcriptional regulations of certain mRNA species. We studied its role in stress response using siRNA mediated knockdown approach in HeLa cells. Upon transient transfection with plasmid encoding siRNA, the cells showed increased sensitivities to various chemical agents, namely H2O2, paraquat, camptothecin, ICRF-193 and halogenated deoxyuridines. These results demonstrate that hnRNP C1/C2 is involved in maintenance of cellular homeostasis besides cellular differentiation and proliferation.
