A Low Cytotoxic Cationic Metal-Organic Framework Carrier for Controllable Drug Release
A Low Cytotoxic Cationic Metal-Organic Framework Carrier for Controllable Drug Release
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一种用于可控药物释放的低细胞毒性阳离子金属有机框架载体
DOI：
10.1021/jm5004107
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发表时间：
2014-07-10
影响因子：
7.3
通讯作者：
Yang, Yu
中科院分区：
文献类型：
--
作者：
Hu, Quan;Yu, Jiancan;Yang, Yu
通过氧化中性晶体MOF-74-Fe（10.通过3-（4，5-二甲基噻唑-2-基）-2，S-二苯基四唑（MTT）测定，该阳离子主体材料对PC 12细胞表现出非常低的细胞毒性，并且通过离子交换和盐渗透程序，该阳离子主体材料表现出布洛芬阴离子的高载药量（类似于15.9wt%）。在阴离子交换控制下，由于配位或游离布洛芬阴离子的存在，药物释放过程中涉及两种机制，具有不同的药物递送速率，使药物释放的给药更加灵活。
A positively charged porous drug carrier MOF-74-Fe(III) (1, MOF = metal-organic framework), which could not be directly synthesized using ferric salts, was prepared through the oxidation of the neutral crystal MOF-74-Fe(10. This cationic host material exhibits very low cytotoxicity upon PC12 cells by 3-(4,5-dimethylthiazol-2-yl)-2,S-diphenyl tetrazolium (MTT) assay and high drug loading capacity of ibuprofen anions (similar to 15.9 wt %) through ion exchange and salt penetration procedures. Controlled by anion exchange, two mechanisms were involved in the drug release process with different drug delivery rates due to the presence of coordinated or free ibuprofen anions, making the administration of drug release more flexible.