Neural substrate of antisaccades -: Role of subcortical structures
Neural substrate of antisaccades -: Role of subcortical structures
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DOI：
10.1212/01.wnl.0000142990.44979.5a
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发表时间：
2004-11-09
期刊：
影响因子：
9.9
通讯作者：
Gaymard, B
中科院分区：
文献类型：
--
作者：
Condy, C;Rivaud-Péchoux, S;Gaymard, B
背景：实验和临床研究表明，背外侧前额叶皮层 (DLPFC) 和上丘 (SC) 对于消除分散注意力的刺激的反射性眼球运动至关重要。然而，皮层下结构的贡献仍然未知。基底神经节在 DLPFC 和 SC 之间提供连续的强直抑制连接，因此可能参与防止触发不必要的眼跳。 DLPFC 还可以通过在内囊 (IC) 中传播的直接前额顶盖通路对 SC 发挥抑制作用。由于丘脑功能障碍可能是 DLPFC 激活减少的原因，因此可以假设丘脑也可能参与扫视抑制。方法：作者记录了 29 名影响纹状体、丘脑或 IC 的单一病变患者的反射性眼跳触发（前眼跳任务）和抑制（反眼跳任务），并将这些结果与对照受试者进行比较。结果：在以下患者中发现抗眼跳任务的错误率正常：1) 基底神经节病变，2) 丘脑病变，或 3) 病变仅限于 IC 后肢的后半部。在病变影响前肢、膝部或 IC 后肢前半部的患者中，发现抗眼跳任务的错误率增加。结论：这些结果表明基底神经节和丘脑在反射性眼跳抑制中均不起主要作用，但支持 DLPFC 直接抑制控制 SC 上眼跳触发的假设。
Background: Experimental and clinical studies suggest that the dorsolateral prefrontal cortex (DLPFC) and the superior colliculus (SC) are crucial for the cancellation of reflexive eye movements toward distracting stimuli. However, the contribution of subcortical structures remains unknown. The basal ganglia provide serial tonic inhibitory connections between the DLPFC and the SC, and could therefore be involved in preventing the triggering of unnecessary saccades. The DLPFC could also exert its inhibitory effect on the SC through direct prefronto-tectal pathways that travel in the internal capsule (IC). Since thalamic dysfunction may be responsible for reduced DLPFC activation, it may be hypothesized that the thalamus could also participate in saccadic inhibition. Methods: The authors recorded reflexive saccade triggering (prosaccade task) and inhibition (antisaccade task) in 29 patients with a single lesion affecting the striatum, the thalamus, or the IC, and compared these results to control subjects. Results: A normal error rate in the antisaccade task was found in patients with 1) a basal ganglia lesion, 2) a thalamic lesion, or 3) a lesion restricted to the posterior half of the posterior limb of the IC. An increased error rate in the antisaccade task was found in patients with a lesion affecting the anterior limb, the genu, or the anterior half of the posterior limb of the IC. Conclusion: These results suggest that neither the basal ganglia nor the thalamus plays a major role in reflexive saccade suppression, but support the hypothesis of a direct DLPFC inhibitory control of saccade triggering on the SC.