The collagen superfamily: from the extracellular matrix to the cell membrane
The collagen superfamily: from the extracellular matrix to the cell membrane
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DOI：
10.1016/j.patbio.2004.12.024
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发表时间：
2005-09-01
影响因子：
--
通讯作者：
Ruggiero, F
中科院分区：
文献类型：
--
作者：
Ricard-Blum, S;Ruggiero, F
胶原蛋白超家族高度复杂，在分子和超分子组织、组织分布和功能上表现出显著的多样性。然而，它的所有成员都有一个共同的结构特征，即至少存在一个三螺旋结构域，对应于氨基酸序列中的许多(Gly-X-Y)n重复(X经常是Pro和Y-HPro)。根据序列同源性以及结构组织和超分子组装的相似性，确定了几个亚家族。在本综述中，我们重点介绍了新发现的纤维性胶原蛋白、间断性三螺旋纤维相关胶原蛋白、膜型胶原蛋白和复合蛋白。还讨论了含有三螺旋结构域但不称为胶原蛋白的蛋白质的最新研究进展。(C)2005年爱思唯尔集团。版权所有。
The collagen superfamily is highly complex and shows a remarkable diversity in molecular and supramolecular organization, tissue distribution and function. However, all its members share a common structural feature, the presence of at least one triple-helical domain, which corresponds to a number of (Gly-X-Y)n repeats (X being frequently proline and Y hydroxyproline) in the amino acid sequence. Several sub-families have been determined according to sequence homologies and to similarities in the structural organization and supramolecular assembly. In the present review, we focus on the newly described fibrillar collagens, fibrillar-associated collagens with interrupted triple helix, membrane collagens and multiplexins. Recent advances in the characterization of proteins containing triple-helical domains but not referred to as collagens are also discussed. (C) 2005 Elsevier SAS. All rights reserved.