Furosemide is associated with acute kidney injury in critically ill patients.
Furosemide is associated with acute kidney injury in critically ill patients.
复制标题
DOI：
10.1590/s0100-879x2012007500093
复制
发表时间：
2012-09
期刊：
影响因子：
--
通讯作者：
Cruz CM
中科院分区：
文献类型：
--
作者：
Levi TM;Rocha MS;Almeida DN;Martins RT;Silva MG;Santana NC;Sanjuan IT;Cruz CM
急性肾损伤(AKI)在危重病人中很常见。利尿剂的使用没有任何证据表明对肾功能有有益的影响。本研究的目的是确定重症监护病房(ICU)AKI的发生率，以及速尿的使用与AKI的发生之间是否存在关联。这项研究涉及一个医院队列，其中344名患者从2010年1月到2011年1月连续入选。纳入病例132例，其中女性75例，男性57例，平均年龄岁。大部分排除与前24 内ICU出院有关。收集实验室、社会人口学和临床数据，直到发生急性心肌梗死、医疗出院或患者死亡。急性肾损伤的发生率为55%(95%CI=46-)。单因素分析发现感染性休克：OR=3.12，95%CI=1.36~7.14；速尿的使用：OR=3.27，95%CI=1.57~6.80；年龄：OR=1.02，95%CI=1.00~1.04。对感染性休克患者亚组的分析显示，速尿发生AKI的优势比为5.5(95%CI=1.16~26.02)。年龄、速尿的使用和感染性休克是危重患者AKI的预测因素。在败血症/感染性休克患者亚组中使用速尿增加了(68.4%)AKI的发生几率(与整体样本相比(43.9%))
Acute kidney injury (AKI) is common in critically ill patients. Diuretics are used without any evidence demonstrating a beneficial effect on renal function. The objective of the present study is to determine the incidence of AKI in an intensive care unit (ICU) and if there is an association between the use of furosemide and the development of AKI. The study involved a hospital cohort in which 344 patients were consecutively enrolled from January 2010 to January 2011. A total of 132 patients (75 females and 57 males, average age 64 years) remained for analysis. Most exclusions were related to ICU discharge in the first 24 h. Laboratory, sociodemographic and clinical data were collected until the development of AKI, medical discharge or patient death. The incidence of AKI was 55% (95%CI = 46-64). The predictors of AKI found by univariate analysis were septic shock: OR = 3.12, 95%CI = 1.36-7.14; use of furosemide: OR = 3.27, 95%CI = 1.57-6.80, and age: OR = 1.02, 95%CI = 1.00-1.04. Analysis of the subgroup of patients with septic shock showed that the odds ratio of furosemide was 5.5 (95%CI = 1.16-26.02) for development of AKI. Age, use of furosemide, and septic shock were predictors of AKI in critically ill patients. Use of furosemide in the subgroup of patients with sepsis/septic shock increased (68.4%) the chance of development of AKI when compared to the sample as a whole (43.9%)
登录
查看更多内容
影响因子：
158.5
作者：
Rivers, E;Nguyen, B;Tomlanovich, M
通讯作者：
Tomlanovich, M
DOI：
10.1097/01.asn.0000013296.11876.12
发表时间：
2002-05-01
影响因子：
13.6
作者：
Castrop, H;Vitzthum, H;Kurtz, A
通讯作者：
Kurtz, A
影响因子：
8.8
作者：
Ostermann, Marlies;Chang, Rene W. S.
通讯作者：
Chang, Rene W. S.
影响因子：
2.7
作者：
Dobrowolski, L;Badzynska, B;Sadowski, J
通讯作者：
Sadowski, J
影响因子：
2.7
作者：
Dobrowolski, L;Badzynska, B;Sadowski, J
通讯作者：
Sadowski, J