A large outbreak of multiresistant Pseudomonas aeruginosa strains in north-eastern Germany
A large outbreak of multiresistant Pseudomonas aeruginosa strains in north-eastern Germany
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DOI：
10.1093/jac/43.3.415
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发表时间：
1999-03-01
影响因子：
5.2
通讯作者：
Gründling, M
中科院分区：
文献类型：
--
作者：
Panzig, B;Schröder, G;Gründling, M
1996年底在德国东北部首次发现多重耐药铜绿假单胞菌；从那时起，他们主要与重症监护病房的患者隔离。在80例患者中证实了定植/感染，特别是呼吸道感染，菌株对-内酰胺类、碳青霉烯类、氨基糖苷类和喹诺酮类耐药。阿米卡星与头孢吡肟、头孢他啶或哌拉西林/他唑巴坦有体外协同作用。菌株水平转移后进行PFGE，环境中检测到相同的菌株，但感染源未确定。严格的感染控制和临床限制使用碳青霉烯类药物限制了此次疫情的进一步传播。
Multiply-resistant Pseudomonas aeruginosa were first detected in north-eastern Germany at the end of 1996; since then they have been isolated predominantly from patients in intensive care units. Colonization/infection, especially of the respiratory tract, has been demonstrated in 80 patients, with strains resistant to beta-lactams, carbapenems, aminoglycosides and quinolones. Amikacin showed in-vitro synergy with cefepime, ceftazidime or piperacillin/tazobactam. Horizontal transfer of strains was followed by PFGE and identical strains were detected in the environment, but the source of infection was not established. Rigorous infection control and restricted clinical use of carbapenems limited further dissemination of this outbreak.