Sympathetic circuits regulating hepatic glucose metabolism: where we stand.
Sympathetic circuits regulating hepatic glucose metabolism: where we stand.
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调节肝脏葡萄糖代谢的交感神经回路：我们的立场。
DOI：
10.1152/physrev.00005.2023
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发表时间：
2024
影响因子：
33.6
通讯作者：
Derbenev,AndreiV
中科院分区：
文献类型：
--
作者：
Zsombok,Andrea;Desmoulins,LucieD;Derbenev,AndreiV
包括2型糖尿病在内的代谢性疾病的患病率在世界范围内持续增加。虽然有更新和更先进的治疗方法，但目前的治疗方法仍然不足，仍在寻找解决办法。能量稳态的调节，包括葡萄糖代谢，涉及神经系统和外周器官和组织之间的信息交换；因此，开发改变中枢和/或周围神经通路的治疗方法可能是调节全身代谢的另一种解决方案。肝脏葡萄糖的产生和储存是控制血糖的主要机制，而自主神经系统在肝功能的调节中起着重要作用。自主神经系统失衡导致肝脏葡萄糖生成过多，从而导致2型糖尿病的发生和发展。在细胞水平上，神经元活动的变化是自主神经失衡的潜在机制之一；因此，调节参与自主神经外流控制的神经元的兴奋性具有改善血糖状态的潜力。自主神经前神经元的组织特异性亚群差异控制自主神经流出；因此，关于肝脏相关神经元的神经回路和特性的详细信息对于制定通过自主神经调节肝功能的策略是必要的。这篇综述综述了我们目前对参与肝脏交感调节的下丘脑-腹侧脑干-肝脏通路的理解，概述了识别器官相关神经元的策略，并总结了糖尿病患者的神经元可塑性，特别关注室旁核中的肝脏相关神经元。
The prevalence of metabolic disorders, including type 2 diabetes mellitus, continues to increase worldwide. Although newer and more advanced therapies are available, current treatments are still inadequate and the search for solutions remains. The regulation of energy homeostasis, including glucose metabolism, involves an exchange of information between the nervous systems and peripheral organs and tissues; therefore, developing treatments to alter central and/or peripheral neural pathways could be an alternative solution to modulate whole body metabolism. Liver glucose production and storage are major mechanisms controlling glycemia, and the autonomic nervous system plays an important role in the regulation of hepatic functions. Autonomic nervous system imbalance contributes to excessive hepatic glucose production and thus to the development and progression of type 2 diabetes mellitus. At cellular levels, change in neuronal activity is one of the underlying mechanisms of autonomic imbalance; therefore, modulation of the excitability of neurons involved in autonomic outflow governance has the potential to improve glycemic status. Tissue-specific subsets of preautonomic neurons differentially control autonomic outflow; therefore, detailed information about neural circuits and properties of liver-related neurons is necessary for the development of strategies to regulate liver functions via the autonomic nerves. This review provides an overview of our current understanding of the hypothalamus-ventral brainstem-liver pathway involved in the sympathetic regulation of the liver, outlines strategies to identify organ-related neurons, and summarizes neuronal plasticity during diabetic conditions with a particular focus on liver-related neurons in the paraventricular nucleus.
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影响因子：
81.5
作者：
Chaker, Loyal;RazvID, Salmon;Peeters, Robin P.
通讯作者：
Peeters, Robin P.
甲状腺激素受体α或β缺失小鼠的心脏离子通道表达和收缩功能。
DOI：
10.1210/endo.142.2.7935
发表时间：
2001
期刊：
Endocrinology.
影响因子：
--
作者：
Gloss,B;Trost,S;Bluhm,W;Swanson,E;Clark,R;Winkfein,R;Janzen,K;Giles,W;Chassande,O;Samarut,J;Dillmann,W
通讯作者：
Dillmann,W
影响因子：
5
作者：
Tavi, P;Sjögren, M;Westerblad, H
通讯作者：
Westerblad, H
表观遗传学的代谢调节。
影响因子：
29
作者：
Lu C;Thompson CB
通讯作者：
Thompson CB
影响因子：
7.1
作者：
Lumey, L. H.;Stein, Aryeh D.;Romijn, J. A.
通讯作者：
Romijn, J. A.