Hypothesis: Smoking decreases breast feeding duration by suppressing prolactin secretion
Hypothesis: Smoking decreases breast feeding duration by suppressing prolactin secretion
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DOI：
10.1016/j.mehy.2013.07.007
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发表时间：
2013-10-01
影响因子：
4.7
通讯作者：
Moghadasian, Mohammed F.
中科院分区：
文献类型：
--
作者：
Bahadori, Babak;Riediger, Natalie D.;Moghadasian, Mohammed F.
许多研究（包括此处总结的新数据）得出的结论是，吸烟母亲的母乳喂养时间较短。尽管有些人认为这仅仅反映了那些容易吸烟的人健康动机不佳，但一些证据支持这样的观点：长期吸烟确实会通过抑制催乳素分泌从而减少母乳量来损害母乳喂养。此外，最近的一项临床试验表明，有效的戒烟计划可以延长吸烟者的母乳喂养时间。对相关啮齿动物研究的分析表明，长期服用尼古丁会增强结节漏斗部的多巴胺能活性，从而抑制催乳素的释放；多巴胺能活性的增加反过来可能反映了尼古丁介导的对下丘脑阿片类药物活性的抑制。 (C) 2013 Elsevier Ltd. 保留所有权利。
A number of studies, including new data summarized here, conclude that breast feeding duration is lower in smoking mothers. Although some have suggested that this merely reflects poor health motivation in those prone to smoke, several lines of evidence support the view that chronic smoking does indeed compromise breast feeding by suppressing prolactin secretion and thereby lowering breast milk volume. Moreover, a recent clinical trial shows that an effective smoking cessation program can boost breast feeding duration in smokers. An analysis of pertinent rodents studies suggests that chronic nicotine administration boosts dopaminergic activity in the tuberoinfundibular tract which functions to inhibit prolactin release; this increase in dopaminergic activity, in turn, may reflect a nicotine-mediated suppression of hypothalamic opioid activity. (C) 2013 Elsevier Ltd. All rights reserved.