Effect of Anticholinergics (Atropine, glycopyrrolate) and prokinetics (Metoclopramide, Cisapride) on gastric motility in beagles and Labrador retrievers
Effect of Anticholinergics (Atropine, glycopyrrolate) and prokinetics (Metoclopramide, Cisapride) on gastric motility in beagles and Labrador retrievers
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DOI：
10.1111/j.1439-0442.2006.00787.x
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发表时间：
2006-03-01
期刊：
影响因子：
--
通讯作者：
Arnold, S
中科院分区：
文献类型：
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作者：
Burger, DM;Wiestner, T;Arnold, S
阿托品、甘草次酸、甲氧氯普胺和西沙必利油对8只犬(4只比格犬和4只拉布拉多犬)胃窦运动的影响。两种抗胆碱药物均可显著且持久地降低收缩的强度和频率。Beagle犬的胃窦运动受到明显的剂量相关抑制，两种活性物质的抑制作用相似。小剂量阿托品(0.02 mg/kg体重肌注)和甘草次酸(0.005 mg/kg体重肌肉注射)完全抑制胃运动至少30min。在拉布拉多犬，两种活性物质的作用没有明显的剂量相关性，甘草次酸的作用至少持续6h，而阿托品的作用在3h后逐渐减弱，两种促动力油对胃窦运动的影响也存在明显的品种差异。在Beagle，低剂量(甲氧氯普胺0.3 mg/kg体重，西沙必利0.2 mg/kg体重)的前动力学可使幅度积分显著增加。高剂量(甲氧氯普胺0.6 mg/kgbw、西沙必利0.5 mg/kgbw)也增加了压力分布的积分，但显著低于低剂量。在拉布拉多犬中，两种药物都会导致收缩幅度的增加，主要是在较高剂量下。低剂量无(西沙必利)或仅有一过性作用(甲氧氯普胺)。胃窦收缩频率完全不受西沙必利的影响，只有比格犬的胃复安引起剂量相关的增加。目前还不清楚拉布拉多犬和比格犬的不同结果是因为品种还是体重。
The effect of atropine, glycopyrrolate, metoclopramide and cisapride oil the antral motility was investigated in eight dogs (four Beagles and four Labradors) using passive telemetry. Both anticholinergics induced a pronounced and lasting reduction of the intensity and frequency of the contractions. A definite dose-related inhibition of the antral motility was seen in Beagles, similar for both active substances. Low doses of atropine (0.02 mg/kg BW i.m.) and glycopyrrolate (0.005 mg/kg BW i.m.) completely inhibited the gastric motility for at least 30 min. whereas higher doses (0.04 or 0.01 ing/kg BW) caused a cessation of activity for more than 3 h. In Labradors, the effects of both active substances were not so dose related and the effect of glycopyrrolate lasted at least 6 h, whereas the effect of atropine gradually decreased after 3 h. A distinct breed difference regarding the effect of the two prokinetics oil the antral motility was also observed. In Beagles, the prokinetics, at a low dose (metoclopramide 0.3 mg/kg BW, cisapride 0.2 mg/kg BW), resulted in a significant increase in the amplitude integral. Higher doses (metoclopramide 0.6 mg/kg BW, cisapride 0.5 mg/kg BW) also increased the integrals of the pressure profiles, but significantly less than with the lower doses. In Labradors, both medications, mainly at higher doses, resulted in an increase of the contraction amplitudes. The low dose had no (cisapride) or only a transient effect (metoclopramide). The frequency of the antral contractions was not at all influenced by cisapride, and only in Beagles metoclopramide resulted in a dose-related increase. It is not clear if the different results in Labradors and Beagles are because of breed or body weight.