Association between DRD2/ANKK1 TaqIA polymorphism and common illicit drug dependence: Evidence from a meta-analysis
Association between DRD2/ANKK1 TaqIA polymorphism and common illicit drug dependence: Evidence from a meta-analysis
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DOI：
10.1016/j.humimm.2014.12.005
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发表时间：
2015-01-01
期刊：
影响因子：
2.7
通讯作者：
Liu, Yun
中科院分区：
文献类型：
--
作者：
Deng, Xiao-Dong;Jiang, Hai;Liu, Yun
背景：越来越多的证据表明，多巴胺受体D2 (DRD2)/激酶结构域1基因（ANKK1） TaqIA单核苷酸多态性（rs1800497）与兴奋剂、阿片类药物和大麻等常见非法药物依赖风险的结果相互矛盾。我们进行了一项荟萃分析，以评估多态性与常见非法药物依赖风险之间的关系。方法：截至2013年10月，共25项现有研究（26个亚组）对多态性与常见非法药物依赖的相关性进行分析。合并优势比（ORs）和95%置信区间（Cl）在适当时使用固定效应和随机效应模型进行估计。评估异质性和发表偏倚。结果：我们发现DRD2/ANKK1 TaqIA多态性在纯合子、显性和隐性遗传模型下分别与阿片类药物依赖风险增加显著相关（纯合子OR = 1.546, 95%CI = 1.279 ~ 1.87；显性OR = 1.265, 95%CI = 1.055 ~ 1.516；隐性OR = 1.409, 95%CI = 1.182 ~ 1.680）。亚组分析的结果与按种族和质量评分的总人口的结果相似。此外，我们还发现高加索和低质量的研究是阿片类药物依赖异质性的主要来源。我们没有发现多态性与兴奋剂或大麻之间的任何显著关联，无论是在总体上还是在任何遗传模型下的亚群分析中。结论：目前的荟萃分析表明，DRD2/ANKK1 TaqIA多态性可能与阿片类药物依赖风险相关，但与兴奋剂或大麻依赖无关。(C) 2014年由Elsevier Inc.代表美国组织相容性和免疫遗传学学会出版。
Background: Growing evidence indicated conflicting results about the dopamine receptor D2 (DRD2)/kinase domain containing 1 gene (ANKK1) TaqIA single nucleotide polymorphism (rs1800497) and common illicit drug dependence risk including stimulants, opioid and marijuana. We conducted a meta-analysis to evaluate the association between the polymorphism and common illicit drug dependence risk.Method: A total of 25 available studies (26 subgroups) testing the association between the polymorphism and common illicit drug dependence were examined through Oct 2013. Pooled-odds ratios (ORs) and 95% confidence intervals (Cl) were estimated using fixed- and random-effects models when appropriate. Heterogeneity and publication bias were evaluated.Results: We found the DRD2/ANKK1 TaqIA polymorphism was significantly associated with increased risk of opioid dependence under homozygote, dominant, and recessive genetic model, respectively (homozygote: OR = 1.546, 95%CI = 1.279-1.87; dominant: OR = 1.265, 95%CI = 1.055-1.516; recessive: OR = 1.409, 95%CI = 1.182-1.680). Subgroup analyses were similar to the results of the total population by ethnicity and quality score. Besides, we also found that Caucasian and low-quality studies were major sources of heterogeneity for opioid dependence. We failed to find any significant association between the polymorphism and stimulants or marijuana neither in total population nor subgroup analyses under any genetic model.Conclusions: The current meta-analysis suggested that DRD2/ANKK1 TaqIA polymorphism might be associated with opioid dependence risk, but not associated with stimulants or marijuana dependence. (C) 2014 Published by Elsevier Inc. on behalf of American Society for Histocompatibility and Immunogenetics.