TOWARDS A GENERAL FUNCTION DESCRIBING T-CELL PROLIFERATION
TOWARDS A GENERAL FUNCTION DESCRIBING T-CELL PROLIFERATION
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DOI：
10.1006/jtbi.1995.0165
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发表时间：
1995-08-21
影响因子：
2
通讯作者：
PERELSON, AS
中科院分区：
文献类型：
--
作者：
DEBOER, RJ;PERELSON, AS
提出了一个新的函数来描述T细胞对抗原提呈细胞上的多肽的反应增殖率。该模型通过允许T细胞的真实最大增殖率来改进我们早期的模型。这是通过简单地改变变量来实现的，这显著地放宽了传统准稳态假设的条件。新模型与以前的模型具有相同的“生态”特性。因此，模型中的自然竞争允许在抗原持续刺激的情况下调节T细胞群体的大小。一个重要的特征是识别具有不同亲和力的相同多肽的T细胞克隆被竞争性排除，从而允许“亲和力选择”。此外，还建立了经验T细胞、初始T细胞和活化T细胞的种群动态模型。这些T细胞亚群相互竞争抗原。在有淋巴因子产生的模型中，获得了允许耐受的‘’增殖阈值‘’。(C)1995年学术出版社有限公司
A new function is proposed for describing the rate of T cell proliferation in response to peptides on antigen-presenting cells. The model improves an earlier model of ours by allowing for a true maximum proliferation rate of the T cells. This is achieved by a simple change of variables that markedly relaxes the conditions for a conventional quasi-steady-state assumption. The new model has the same ''ecological'' properties as the previous one. Thus the natural competition in the model allows for regulation of T cell population size in the presence of continuous stimulation by antigen. An important feature is the competitive exclusion of T cell clones recognizing the same peptide with different affinities allowing for ''affinity selection''. Models for the population dynamics of experienced, naive and activated T cells are also developed. These T cell subpopulations compete with one another for antigen. In models with lymphokine production a ''proliferation threshold'' is obtained that allows for tolerance. (C) 1995 Academic Press Limited