Transplacental effects of diethylnitrosamine in Syrian hamsters as related to different days of administration during pregnancy.
Transplacental effects of diethylnitrosamine in Syrian hamsters as related to different days of administration during pregnancy.
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二乙基亚硝胺对叙利亚仓鼠的经胎盘影响与怀孕期间不同给药天数有关。
DOI：
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发表时间：
1975
期刊：
影响因子：
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通讯作者：
J. Hilfrich
中科院分区：
文献类型：
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作者：
U. Mohr;H. Reznik;G. Reznik;J. Hilfrich
雌性叙利亚仓鼠在妊娠15天中的1天单次皮下注射45 mg二乙基亚硝胺（DEN）/kg体重。在妊娠前11天中的1天给药的雌性动物的后代中，没有发现呼吸道肿瘤。在妊娠后4天（12-15天）中的1天给药的雌性动物的后代中，呼吸道肿瘤的发生率高达95%。其他器官中肿瘤的发生率较低，似乎与DEN治疗日期无关。
Female Syrian hamsters were given a single sc dose of 45 mg diethylnitrosamine (DEN)/kg body weight on 1 of the 15 days of pregnancy. In the offspring of females treated on 1 of the first 11 days of pregnancy, no respiratory tract tumors were found. The offspring of mothers given DEN on 1 of the last 4 days (12-15) of pregnancy developed respiratory tract neoplasms at a rate of up to 95%. A lower incidence of tumors in other organs seemed independent of the day of DEN treatment.