Kawasaki Disease Hospitalizations in the United States 2016-2020: A Comparison of Before and During the Coronavirus Disease 2019 Era.
Kawasaki Disease Hospitalizations in the United States 2016-2020: A Comparison of Before and During the Coronavirus Disease 2019 Era.
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DOI：
10.1097/inf.0000000000003289
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发表时间：
2021-11-01
期刊：
影响因子：
--
通讯作者：
Sturm J
中科院分区：
文献类型：
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作者：
Phamduy TT;Smith S;Herbst KW;Phamduy PT;Brimacombe M;Hogan AH;Salazar JC;Sturm J
川崎疾病（KD）是幼儿的急性血管炎。
使用大型住院数据库，我们进行了回顾性队列研究，并分析了（1）（1）诊断KD诊断的患者的数据，（2）IV免疫球蛋白治疗在住院期间和（3）在2016年1月1日，2016年1月1日至2020年12月30日之间的出院日期。
从2016年到2019年的KD住院数量稳定（n = 1652，1796，1748，1692），但在2020年进行了改善（n = 1383年），季节性差异显示出在2020年5月2020年的第二个峰值。 2016- 2019年（p <0.01）。
与过去的四年相比，每年的儿科KD入院人数减少了，而在2020年，KD的诊断代码通常年龄较大，更有可能反映出诊所的多系统炎症综合症的儿童的临床医生可能会在2019年的KD率上升。与KD返回相关。
Kawasaki disease (KD) is an acute vasculitis of young children. A comparison of US hospitalization rates and epidemiologic features of KD in 2020 to those of precoronavirus disease years has yet to be reported. Using a large, inpatient database, we conducted a retrospective cohort study and analyzed data for patients with (1) diagnosis coding for KD, (2) IV immunoglobulin treatment administered during hospitalization and (3) discharge date between January 1, 2016, and December 30, 2020. Severe cases were defined as those requiring adjunctive therapy or IV immunoglobulin–resistant therapy. The annual number of KD hospitalizations were stable from 2016 to 2019 (n = 1652, 1796, 1748, 1692, respectively) but decreased in 2020 (n = 1383). KD hospitalizations demonstrated seasonal variation with an annual peak between December and April. A second peak of KD admissions was observed in May 2020. The proportion of KD cases classified as severe increased to 40% in 2020 from 33% during the years 2016–2019 (P < 0.01). Median age in years increased from 2.9 in subjects hospitalized from 2016 to 2019 to 3.2 in 2020 (P = 0.002). Compared with the previous 4 years, the annual number of pediatric KD admissions decreased, and children discharged with diagnostic codes for KD in 2020 were generally older and more likely to have severe morbidity possibly reflective of misdiagnosed multisystem inflammatory syndrome in children. Clinicians should be wary of a possible rise in KD rates in the postcoronavirus disease 2019 era as social distancing policies are lifted and other viruses associated with KD return.