Learning rules and persistence of dendritic spines
Learning rules and persistence of dendritic spines
复制标题
DOI：
10.1111/j.1460-9568.2010.07344.x
复制
发表时间：
2010-07-01
影响因子：
3.4
通讯作者：
Noguchi, Jun
中科院分区：
文献类型：
--
作者：
Kasai, Haruo;Hayama, Tatsuya;Noguchi, Jun
树突棘的结构可塑性是大脑皮层学习、记忆和认知的基础。我们在这里总结了脊柱结构可塑性的15条规则，或“脊柱学习规则”。总之，他们提出了脊椎的自发产生、选择和强化（SGSS）是如何代表学习和记忆的物理基础的。这一机制与Hebb的学习规则一致，但暗示了突触可塑性与记忆之间的新关系。我们描述了脊柱学习规则的细胞和分子基础，例如脊柱结构的持久性和肌动蛋白的基本作用，肌动蛋白聚合形成“记忆凝胶”，这是选择和加强脊柱突触所必需的。我们还讨论了结构可塑性的转录和翻译调节之间的可能联系。SGSS机制和脊柱学习规则阐明了实际脑组织中神经元网络操作中突触可塑性的整体性质。
Structural plasticity of dendritic spines underlies learning, memory and cognition in the cerebral cortex. We here summarize fifteen rules of spine structural plasticity, or 'spine learning rules.' Together, they suggest how the spontaneous generation, selection and strengthening (SGSS) of spines represents the physical basis for learning and memory. This SGSS mechanism is consistent with Hebb's learning rule but suggests new relations between synaptic plasticity and memory. We describe the cellular and molecular bases of the spine learning rules, such as the persistence of spine structures and the fundamental role of actin, which polymerizes to form a 'memory gel' required for the selection and strengthening of spine synapses. We also discuss the possible link between transcriptional and translational regulation of structural plasticity. The SGSS mechanism and spine learning rules elucidate the integral nature of synaptic plasticity in neuronal network operations within the actual brain tissue.