Chromosome analysis of workers occupationally exposed to radiation at the Sellafield nuclear facility.
Chromosome analysis of workers occupationally exposed to radiation at the Sellafield nuclear facility.
复制标题
对塞拉菲尔德核设施中职业暴露于辐射的工人进行染色体分析。
DOI：
10.1080/095530000138691
复制
发表时间：
2000
影响因子：
2.6
通讯作者：
Tarone,RE
中科院分区：
文献类型：
--
作者：
Tawn,EJ;Whitehouse,CA;Holdsworth,D;Morris,S;Tarone,RE
PurposeTo探讨外周血淋巴细胞稳定染色体畸变频率与职业累积辐射暴露之间的关系。材料和方法对104名来自英国核燃料公司塞拉菲尔德工厂的工人的外周血淋巴细胞培养物进行G显带细胞遗传学分析。研究组包括61名男子与终身累积剂量> 500毫希沃特，39名男子与最小的曝光（即< 50毫希沃特）谁形成了一个控制组和4名男子与中间dosage.ResultsThe剂量反应的斜率，调整吸烟状态，易位和插入为0.55 +/- 0.31 × 10 - 2/细胞/Sv。考虑染色体断裂点的所有畸变结合在放射工作者揭示了过量的C组染色体和赤字的F组染色体断裂点集中在终端区域，而在对照组的分布并没有偏离expectation.ConclusionsThe剂量反应是没有显着不同的平行FISH分析（Tucker等人，1997年），并证实，与急性辐照相比，慢性辐照在诱导稳定染色体畸变方面的效果似乎要小得多。
PurposeTo investigate the relationship between stable chromosome aberration frequency in peripheral blood lymphocytes and occupational cumulative radiation exposure.Materials and methodsCytogenetic analysis using G-banding was performed on peripheral blood lymphocyte cultures from 104 workers from the British Nuclear Fuels PLC facility at Sellafield, UK. The study group comprised 61 men with lifetime cumulative doses > 500mSv, 39 men with minimal exposure (i.e. < 50 mSv) who formed a control group and 4 men with intermediate doses.ResultsThe slope of the dose-response, adjusted for smoking status, for translocations and insertions was 0.55 +/- 0.31 x 10 -2 /cell/Sv. Consideration of chromosome breakpoints for all aberrations combined in the radiation workers revealed an excess in the C group chromosomes and a deficit in the F group chromosomes with breakpoints being concentrated in the terminal regions whereas the distribution in the control group did not deviate from expectation.ConclusionsThe dose-response was not significantly different from the parallel FISH analysis (Tucker et al. 1997) and confirms that chronic radiation exposure appears to be substantially less effective at inducing stable chromosome aberrations in comparison with acute exposure.