EFFECTS OF VARIOUS DRUGS ON BLADDER FUNCTION IN CONSCIOUS RESTRAINED-DENERVATED RATS PLACED IN A RESTRAINING CAGE AND PRODUCED BY TRANSECTION OF THE HYPOGASTRIC NERVE
EFFECTS OF VARIOUS DRUGS ON BLADDER FUNCTION IN CONSCIOUS RESTRAINED-DENERVATED RATS PLACED IN A RESTRAINING CAGE AND PRODUCED BY TRANSECTION OF THE HYPOGASTRIC NERVE
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DOI：
10.1254/jjp.52.405
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发表时间：
1990-03-01
期刊：
影响因子：
--
通讯作者：
GOMI, Y
中科院分区：
文献类型：
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作者：
MORIKAWA, K;KAKIUCHI, M;GOMI, Y
我们评估了各种静脉注射药物的影响，这些药物已被证明会影响麻醉和/或清醒大鼠的膀胱功能，对置于限制笼中的意识受限去神经大鼠（通过横断腹下神经产生）的膀胱图的影响，并与置于限制笼中的意识受限完整大鼠（腹下神经完整）的膀胱图进行了比较。去神经抑制大鼠膀胱容量小于完整抑制大鼠，转宽笼后膀胱容量无变化，但转宽笼后膀胱容量下降。因此，有意识的大鼠的腹下神经的活动似乎受到约束的刺激。阿托品抑制排尿收缩幅度（膀胱图显示排尿时间）。在失神经抑制的大鼠中，硫喷妥钠和吲哚美辛增加膀胱容量的剂量与未受神经抑制的大鼠几乎相同，但增加膀胱容量所需的吗啡剂量高于未受神经抑制的大鼠。这些结果表明，在抑制失神经大鼠的膀胱造影是评估一种不受胃下神经影响的新药物对膀胱功能影响的有效方法。
We evaluated the effects of various intravenously administered drugs, which had been shown to influence bladder function in anesthetized and/or conscious rats, on the cystometrogram in conscious restrained-denervated rats (produced by transection of the hypogastric nerve) placed in a restraining cage in comparison to those in conscious restrained-intact rats (with the hypogastric nerve intact) placed in a restraining cage. The bladder capacity in the restrained-denervated rats was smaller than that in restrained-intact rats and did not change when they were transferred to a wide cage, but the bladder capacity of the restrained-intact rats decreased following transfer to the wide cage. Therefore, the activity of the hypogastric nerve in conscious rats appears to be stimulated by restraint. Atropine suppressed the amplitude of the micturition contraction (time to micturition in the cystometrogram). In the restrained-denervated rats, thiopental and indomethacin increased the bladder capacity at almost the same doses as those in restrained-intact rats, but it took a higher dose of morphine to increase the bladder capacity than in restrained-intacts rats. These findings suggest that cystometrography in restrained-denervated rats is a useful method for evaluating the effect of a newly developed agent on bladder function without any influence from the hypogastric nerve.