A population-based study of animal component sensitization, asthma, and rhinitis in schoolchildren
A population-based study of animal component sensitization, asthma, and rhinitis in schoolchildren
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DOI：
10.1111/pai.12422
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发表时间：
2015-09-01
影响因子：
4.4
通讯作者：
Ronmark, Eva
中科院分区：
文献类型：
--
作者：
Bjerg, Anders;Winberg, Anna;Ronmark, Eva
背景动物致敏是儿童哮喘的主要决定因素。目前缺乏对儿童人群的有效研究。目的是描述动物成分的致敏性和动物致敏的学龄儿童哮喘和鼻炎的关联。MethodsA随机抽样696名儿童（11- 12岁）从瑞典人口为基础的队列进行了测试，猫，狗，马皮屑使用ImmunoCAP的致敏性。动物致敏儿童的血清进一步通过微阵列分析，包括三种猫变应原组分，四种狗变应原组分和两种马变应原组分。父母完成了扩大ISAAC questionnaire.ResultsOf 259动物致敏儿童（0.1 kU（A）/L），51%的敏感，所有三个，23%的两个，和25%的一个物种。当前哮喘和与猫接触后的哮喘症状与对Fel d 1和Fel d 4的共致敏相关。这种关联已经在对Fel d 4的中等水平致敏（1-15 ISU）中观察到，在该水平下，大多数儿童也对Fel d 1敏感。在狗致敏的儿童中，大多数对一种以上的狗成分致敏，对Can f 5和Can f 1/f 2的共同致敏赋予哮喘最大的风险。致敏的高度交叉反应的血清白蛋白是罕见的，并不与asthma.ConclusionsAmong学童在北方瑞典，螨过敏是罕见的，毛茸茸的动物是主要的常年致敏。哮喘与更高水平的成分致敏相关，对同一动物的一种以上成分致敏的风险最大。
BackgroundAnimal sensitization is a major determinant of asthma in children. Component-resolved studies of unselected pediatric populations are lacking. The aim was to describe sensitization to animal components and the association with asthma and rhinitis in animal-sensitized schoolchildren.MethodsA random sample of 696 children (11-12years) from a Swedish population-based cohort was tested for sensitization to cat, dog, and horse dander using ImmunoCAP. Sera from animal-sensitized children were further analyzed by microarray including three allergen components from cat, four from dog, and two from horse. The parents completed an expanded ISAAC questionnaire.ResultsOf 259 animal-sensitized children (0.1 kU(A)/l), 51% were sensitized to all three, 23% to two, and 25% to one species. Current asthma and asthma symptoms following contact with cats were associated with co-sensitization to Fel d 1 and Fel d 4. This association was seen already at moderate-level sensitization (1-15 ISU) to Fel d 4, at which level most children were sensitized to Fel d 1, as well. In dog-sensitized children, the majority was sensitized to more than one dog component, and co-sensitization to Can f 5 and Can f 1/f 2 conferred the greatest risk for asthma. Sensitization to the highly cross-reactive serum albumins was uncommon and not associated with asthma.ConclusionsAmong schoolchildren in northern Sweden, where mite allergy is uncommon, furry animals were the primary perennial sensitizers. Asthma was associated with higher levels of component sensitization, and sensitization to more than one component from the same animal conferred the greatest risk.