Androgen receptor locus on the human X chromosome: regional localization to Xq11-12 and description of a DNA polymorphism.
Androgen receptor locus on the human X chromosome: regional localization to Xq11-12 and description of a DNA polymorphism.
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DOI：
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发表时间：
1989-02
影响因子：
9.8
通讯作者：
Carolyn J. Brown;S. Goss;D. Lubahn;D. R. Joseph;E. Wilson;F. S. French;H. Willard
中科院分区：
文献类型：
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作者：
Carolyn J. Brown;S. Goss;D. Lubahn;D. R. Joseph;E. Wilson;F. S. French;H. Willard
雄激素受体的基因，即引起X连锁雄激素不敏感综合征的突变，已经通过分析定位于人X染色体的q11-q12区域，使用雄激素受体的克隆cDNA，分离X染色体的部分的体细胞杂交板。一个中等频率的HindIII RFLP已被发现，这应该是有用的遗传连锁分析的各种遗传形式的雄激素不敏感。
The gene for the androgen receptor, mutations at which cause the X-linked androgen insensitivity syndrome, has been localized to the q11----q12 region of the human X chromosome by analysis, using a cloned cDNA for the androgen receptor, of somatic cell hybrid panels segregating portions of the X chromosome. A moderate-frequency HindIII RFLP has been found which should be useful in genetic linkage analysis of the various inherited forms of androgen insensitivity.