ULTRASONICALLY INDUCED GAS BUBBLE PRODUCTION IN AGAR BASED GELS .1. EXPERIMENTAL INVESTIGATION
ULTRASONICALLY INDUCED GAS BUBBLE PRODUCTION IN AGAR BASED GELS .1. EXPERIMENTAL INVESTIGATION
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DOI：
10.1016/0301-5629(87)90179-7
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发表时间：
1987-09-01
影响因子：
2.9
通讯作者：
DYSON, M
中科院分区：
文献类型：
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作者：
DANIELS, S;BLONDEL, D;DYSON, M
通过用频率为0.75 - 3.0 MHz的连续或脉冲超声辐照，可在琼脂基凝胶中产生肉眼可见的气泡。随频率、声压、脉冲长度、占空比和温度形成的气泡数量的变化与体内观察到的非常相似。此外，引发气泡形成所需的声压也接近于体内所需的声压。已经观察到，凝胶的浓度和pH的改变可以对气泡的性质和数量产生深远的影响。这表明，不仅是这种凝胶模型适用于在体内的气泡形成的宏观特征的表示，但可以用于获得在体内的信息，但可以用于获得有关预先存在的气泡核的信息。基于所获得的实验结果，可以建议，对于高达1 MPa的峰值负声压（对于平面行进正弦波，相当于30 W/cm 2的时间平均强度），可以通过使用高频率、短脉冲长度和长占空比来避免气泡形成。
Macroscopically visible gas bubbles can be produced in an agar based gel by irradiation with either continuous or pulsed ultrasound at frequencies from 0.75 to 3.0 MHz. The variation in the number of bubbles formed with frequency, acoustic pressure, pulse length, duty cycle, and temperature closely resembles that seen in vivo. Furthermore, the acoustic pressure required to initiate bubble formation is also close to that required in vivo. It has been observed that alterations in the concentration and pH of the gels can have a profound effect on the nature and quantity of bubbles. This suggests that not only is this gel model suitable for the representation of the macroscopic features of bubble formation in vivo, but can be used to gain information in vivo, but can be used to gain information about the preexisting bubble nuclei. Based on the experimental results obtained it can be suggested that for peak negative acoustic pressures of up 1 MPa (equivalent, for a plane traveling sinusoidal wave, to a time averaged intensity of 30 W/cm2) bubble formation can be avoided by the use of high frequencies, short pulse lengths and long duty cycles.