Ethanol targets:: a BK channel cocktail in C. elegans
Ethanol targets:: a BK channel cocktail in C. elegans
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DOI：
10.1016/j.tins.2004.07.006
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发表时间：
2004-10-01
影响因子：
15.9
通讯作者：
Crowder, CM
中科院分区：
文献类型：
--
作者：
Crowder, CM
对秀丽隐杆线虫乙醇中毒抗性的遗传筛选分离出基因slow -1突变体。slow -1编码一个大电导Ca2+激活的K+通道的成孔亚基，该通道先前被证明可以限制秀丽隐杆线虫的兴奋性神经递质释放。在体内记录的电生理数据与一种模型一致，即乙醇增强SLO-1通过减少兴奋性神经递质释放而导致秀丽隐杆线虫中毒。
A genetic screen for resistance to ethanol intoxication in Caenorhabditis elegans isolated mutants of the gene slo-1. slo-1 encodes the pore-forming subunit of a large-conductance Ca2+-activated K+ channel previously shown to limit excitatory neurotransmitter release in C. elegans. Electrophysiological data recorded in vivo are consistent with a model in which ethanol potentiation of SLO-1 produces intoxication in C. elegans by reducing excitatory neurotransmitter release.