Preparation of submicron particles for theranostic applications : imaging and therapy
Preparation of submicron particles for theranostic applications : imaging and therapy
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发表时间：
2015-11
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通讯作者：
M. Iqbal
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作者：
M. Iqbal
本研究的目的是制备和表征多功能亚微米颗粒，可用于诊断和治疗包括癌症在内的几种致命疾病（即治疗诊断）。为此，进行了系统研究，以优化聚合物颗粒制备的工艺参数，该聚合物颗粒可用作有效递送药物和成像标签的平台。通过双乳化溶剂蒸发技术将显像剂（FluoSpheres®）封装成荧光造影剂，并进行体外评价。然后，采用NaBH4还原法制备金纳米粒子，并用聚己内酯聚合物进行表征和封装，用于体外应用。最后，将金纳米粒子与亲水性药物（奈福泮）和疏水性药物（苯甲酸苄酯）同时负载到聚己内酯颗粒中。然后对制备的颗粒进行物理化学表征并进行体外皮肤渗透研究
The objective of this study was to prepare and characterize multifunctional submicron particles that can be used for diagnosis and therapy of several fatal diseases including cancer (i.e theranostic). For this purpose, a systematic study was performed in order to optimize the process parameters for preparation of polymeric particle that can be used as a platform for effective delivery of drugs and imaging labels. The imaging agent (FluoSpheres®) was encapsulated via double emulsion solvent evaporation technique to be used fluorescent contrast agent and their in vitro evaluation was performed. Then, gold nanoparticles were prepared by using NaBH4 reduction method, characterized and encapsulated by polycaprolactone polymer for in vitro applications. Finally, the gold nanoparticle were loaded into polycaprolactone particle along with a hydrophilic drug (Nefopam) and a hydrophobic drug (benzyl benzoate) simultaneously. The prepared particles were then characterized physicochemically and in vitro skin penetration study was performed