Enhanced Place Specificity of the Parallel Auditory Brainstem Response: An Electrophysiological Study.
Enhanced Place Specificity of the Parallel Auditory Brainstem Response: An Electrophysiological Study.
复制标题
平行听觉脑干反应的增强位置特异性：一项电生理学研究。
DOI：
10.1101/2024.03.10.584313
复制
发表时间：
2024
期刊：
影响因子：
--
通讯作者：
Maddox,RossK
中科院分区：
文献类型：
--
作者：
Stoll,ThomasJ;Maddox,RossK
目的探讨平行刺激对听性脑干反应（ABR）位置特异性的影响。特定频率的刺激并不能保证耳蜗上的反应只对应于该特征频率-特别是对于短暂和高水平的刺激。添加掩蔽噪声会产生更具有位置特异性的响应，我们之前的建模研究表明，当多个频率特异性刺激并行呈现时，会产生类似的效果。我们测试了这个假设实验在这里，比较的地方特异性的反应，串行和并行刺激在两个刺激频率和三个stimulationrates.MethodsParallel ABR（pABR）的刺激一起高通滤波噪声与不同的截止频率。串行演示也进行了测试，通过隔离和提出单频刺激列车从pABR合奏。检查ABR的潜伏期以评估反应的位置特异性。通过减去不同高通噪声条件下的响应，得到响应频带。从每个派生的响应频带的响应幅度，然后使用来确定有多少个人的听觉系统的频率区域的整体response.ResultsWe发现，平行演示提高了ABR的位置特异性较低的刺激频率和较高的刺激率。在较高的刺激频率，串行和并行呈现同样的位置特异性。结论平行呈现可以提供更多的位置特异性反应比串行较低的刺激频率。这种改善随着更高的刺激率而增加，并且是除了pABR的主要优点即更快的测试时间之外的。
PurposeThis study investigates the effect of parallel stimulus presentation on the place specificity of the auditory brainstem response (ABR) in human listeners. Frequency-specific stimuli do not guarantee a response from the place on the cochlea corresponding only to that characteristic frequency — especially for brief and high-level stimuli. Adding masking noise yields responses that are more place specific, and our prior modeling study has suggested similar effects when multiple frequency-specific stimuli are presented in parallel. We tested this hypothesis experimentally here, comparing the place specificity of responses to serial and parallel stimuli at two stimulus frequencies and three stimulus rates.MethodsParallel ABR (pABR) stimuli were presented alongside high-pass filtered noise with a varied cutoff frequency. Serial presentation was also tested by isolating and presenting single-frequency stimulus trains from the pABR ensemble. Latencies of the ABRs were examined to assess place specificity of responses. Response bands were derived by subtracting responses from different high-pass noise conditions. The response amplitude from each derived response band was then used to determine how much individual frequency regions of the auditory system were contributing to the overall response.ResultsWe found that parallel presentation improves place specificity of ABRs for the lower stimulus frequency and at higher stimulus rates. At a higher stimulus frequency, serial and parallel presentations were equally place specific.ConclusionParallel presentation can provide more place-specific responses than serial for lower stimulus frequencies. The improvement increases with higher stimulus rates and is in addition to the pABR’s primary benefit of faster test times.