Combining task-evoked and spontaneous activity to improve pre-operative brain mapping with fMRI.
Combining task-evoked and spontaneous activity to improve pre-operative brain mapping with fMRI.
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DOI：
10.1016/j.neuroimage.2015.09.030
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发表时间：
2016-01-01
期刊：
影响因子：
5.7
通讯作者：
Liu H
中科院分区：
文献类型：
--
作者：
Fox MD;Qian T;Madsen JR;Wang D;Li M;Ge M;Zuo HC;Groppe DM;Mehta AD;Hong B;Liu H
脑功能的无创定位用于了解和治疗神经系统疾病，例如在神经外科干预之前的术前fMRI制图。生成这些地图的主要方法依赖于任务引起的大脑反应，尽管已知有局限性，但在20多年来一直主导着临床实践。最近，基于自发性脑活动相关性的术前fMRI制图已被证实，然而这种方法有其自身的局限性，尚未广泛应用于临床。在这里，我们发现自发和基于任务的映射可以使用相同的术前fMRI数据一起进行，为功能定位提供相关的补充信息，并且可以结合起来提高对流利运动皮层的识别。通过与8例难治性癫痫患者的皮质电刺激图谱比较，量化了我们方法的准确性、敏感性和特异性。通过对来自不同中心的六名患者的独立数据集的前瞻性复制，证明了我们方法的广泛适用性和可重复性。在两个队列和每个个体患者中，我们看到独立于阈值的信号噪声和映射精度的显着改善，使用接受者工作特征曲线进行量化。总的来说，我们的研究结果表明，修改fMRI数据的处理，将任务型和自发活动结合起来，可以显著改善术前患者的功能定位。由于该方法不需要额外的扫描时间，也不需要对传统的术前数据采集协议进行修改，因此具有广泛的实用性。
Noninvasive localization of brain function is used to understand and treat neurological disease, exemplified by pre-operative fMRI mapping prior to neurosurgical intervention. The principal approach for generating these maps relies on brain responses evoked by a task and, despite known limitations, has dominated clinical practice for over 20 years. Recently, pre-operative fMRI mapping based on correlations in spontaneous brain activity has been demonstrated, however this approach has its own limitations and has not seen widespread clinical use. Here we show that spontaneous and task-based mapping can be performed together using the same pre-operative fMRI data, provide complimentary information relevant for functional localization, and can be combined to improve identification of eloquent motor cortex. Accuracy, sensitivity, and specificity of our approach are quantified through comparison with electrical cortical stimulation mapping in eight patients with intractable epilepsy. Broad applicability and reproducibility of our approach is demonstrated through prospective replication in an independent dataset of six patients from a different center. In both cohorts and every individual patient, we see a significant improvement in signal to noise and mapping accuracy independent of threshold, quantified using receiver operating characteristic curves. Collectively, our results suggest that modifying the processing of fMRI data to incorporate both task-based and spontaneous activity significantly improves functional localization in pre-operative patients. Because this method requires no additional scan time or modification to conventional pre-operative data acquisition protocols it could have widespread utility.