INHIBITOR OF APOPTOSIS
INHIBITOR OF APOPTOSIS
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J. Virol
1998年2月3日国际检索报告（PCT/US 97/ 12904）（ARCD：239 P）。Leopardi和Roizman，“单纯疱疹病毒1型主要调节蛋白ICP 4与EAP（一种核仁核糖体蛋白）的功能相互作用和科洛化”，Proc. Natl. Acad. Sci. USA，93：4572-4576，1996. Leopardi和Roizman，“单纯疱疹病毒主要调节蛋白ICP 4阻断由病毒或热疗诱导的细胞凋亡”，Proc. Natl. Acad. Sci. USA，93：9583-9587，1996. Papavassiliou，Wilcox和Silverstein，“ICP 4与细胞/感染细胞因子的相互作用及其磷酸化状态调节单纯疱疹病毒DNA中前导序列的差异识别，EMBO Journal，10（2）：397-406，1991。Xia，Dampe和DeLuca，“蛋白激酶A和单纯疱疹病毒1型ICP 4的丝氨酸富集区在病毒复制中的作用”，病毒学杂志，70（2）：1050-1060，1996。
International Search Report dated Feb. 3, 1998 (PCT/US97/ 12904) (ARCD:239P). Leopardi and Roizman, “Functional interaction and colo calization of the herpes simplex virus 1 major regulatory protein ICP4 with EAP, a nucleolar-ribosomal protein,” Proc. Natl. Acad. Sci. USA, 93:4572–4576, 1996. Leopardi and Roizman, “The herpes simplex virus major regulatory protein ICP4 blocks apoptosis induced by the virus or by the hyperthermia,” Proc. Natl. Acad. Sci. USA, 93:9583-9587, 1996. Papavassiliou, Wilcox and Silverstein, “The interaction of ICP4 with cell/infected-cell factors and its state of phos phorylation modulate differential recognition of leader sequences in herpes simplex virus DNA, EMBO Journal, 10(2):397–406, 1991. Xia, Knipe and DeLuca, “Role of protein kinase A and the Serine-rich region of herpes simplex virus type 1 ICP4 in viral replication,” Journal of Virology, 70(2):1050–1060, 1996.