Dynamic infrared imaging for the detection of malignancy
Dynamic infrared imaging for the detection of malignancy
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DOI：
10.1088/0031-9155/49/14/005
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发表时间：
2004-07-21
影响因子：
3.5
通讯作者：
Weiss, R
中科院分区：
文献类型：
--
作者：
Button, TM;Li, HF;Weiss, R
已经在人类恶性肿瘤的动物模型中研究了使用动态红外成像（DIRI）进行恶性肿瘤检测的潜力。在荷瘤小鼠的血管和心源性频率下形成的图像中，血管扩张是明显的。通过给予阻断一氧化氮（NO）引起的血管舒张的药物消除了恶性肿瘤的观察结果。图像模式类似的恶性肿瘤的特点，可以模仿正常小鼠使用NO产生剂。显然，DIRI允许在该模型中通过由恶性肿瘤产生的NO引起的血管舒张进行癌症检测。通过与激光多普勒血流仪（LDF）进行比较，在人类受试者中验证了血管扩张和心源性表面灌注的动态红外检测。然后将动态红外成像技术应用于乳腺癌检测。结果表明，在正常和恶性乳腺的血管和心源性频率形成的动态红外图像具有图像模式差异，这可能允许乳腺癌检测。
The potential for malignancy detection using dynamic infrared imaging (DIRI) has been investigated in an animal model of human malignancy. Malignancy was apparent in images formed at the vasomotor and cardiogenic frequencies of tumour bearing mice. The observation of malignancy was removed by the administration of an agent that blocks vasodilation caused by nitric oxide (NO). Image patterns similar to those that characterize malignancy could be mimicked in normal mice using an NO producing agent. Apparently DIRI allows for cancer detection in this model through vasodilation caused by malignancy generated NO. Dynamic infrared detection of vasomotor and cardiogenic surface perfusion was validated in human subjects by a comparison with laser Doppler flowmetry (LDF). Dynamic infrared imaging technology was then applied to breast cancer detection. It is shown that dynamic infrared images formed at the vasomotor and cardiogenic frequencies of the normal and malignant breast have image pattern differences, which may allow for breast cancer detection.