7,9-Diaryl-1,6,8-trioxaspiro[4.5]dec-3-en-2-ones: readily accessible and highly potent anticancer compounds.
7,9-Diaryl-1,6,8-trioxaspiro[4.5]dec-3-en-2-ones: readily accessible and highly potent anticancer compounds.
复制标题
7,9-二芳基-1,6,8-三氧螺[4.5]dec-3-en-2-酮：易于获得且高效的抗癌化合物。
DOI：
10.1016/j.bmcl.2014.05.102
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发表时间：
2014
影响因子：
2.7
通讯作者：
Murelli,RyanP
中科院分区：
文献类型：
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作者：
D'Erasmo,MichaelP;Smith,WilliamB;Munoz,Alberto;Mohandas,Poornima;Au,AndrewS;Marineau,JasonJ;Quadri,LuisEN;Bradner,JamesE;Murelli,RyanP
7,9-Diaryl-1,6,8-trioxaspiro[4.5]dec-3-en-2-ones are a recently described group of spirocyclic butenolides that can be generated rapidly and as a single diastereomer through a cascade process between γ-hydroxybutenolides and aromatic aldehydes. The following outlines our findings that these spirocycles are potently cytotoxic and have a dramatic structure–function profile that provides excellent insight into the structural features required for this potency.
