Partner cigarette smoking and risk of neural tube defects among infants of non-smoking women in northern China
Partner cigarette smoking and risk of neural tube defects among infants of non-smoking women in northern China
复制标题
中国北方地区不吸烟女性伴侣吸烟与婴儿神经管缺陷的风险
DOI：
10.1136/tobaccocontrol-2011-050384
复制
发表时间：
2013-11-01
期刊：
影响因子：
5.2
通讯作者：
Ren, Aiguo
中科院分区：
文献类型：
--
作者：
Li, Zhiwen;Zhang, Le;Ren, Aiguo
目的探讨中国非吸烟妇女配偶二手烟暴露对新生儿神经管缺陷（NTDs）风险的影响。方法数据来自中国北方一项正在进行的以人群为基础的外部畸形病例对照研究。病例组包括2002年11月至2007年12月期间确定的580名NTD婴儿或胎儿。对照组为795名无严重外部畸形的新生儿。结果81.4%的病例组妇女和71.8%的对照组妇女的性伴在围受孕期吸烟;与伴侣吸烟相关的NTD的校正OR为1.6（95%CI 1.2至2.1）。与伴侣不吸烟的非吸烟女性相比，伴侣吸烟的女性中暴露于和不暴露于伴侣吸烟的女性的胎儿NTD风险分别为1.7（1.3至2.4）和1.1（0.7至1.7）。在暴露于伴侣吸烟的女性中，NTD的风险分别为1.4（0.9至2.0），1.8（1.2至2.6），1.9（1.2至3.0）和2.7（1.6至4.7）。
Objectives To investigate the effect of secondhand smoke exposure from a partner on the risk of having a newborn baby with neural tube defects (NTDs) in Chinese non-smoking women.Methods Data were derived from an on-going population-based case-control study of external malformations in northern China. The case group included 580 infants or fetuses with NTDs identified between November 2002 and December 2007. Controls were 795 newborn infants without major external malformations. Data were collected by trained health workers through face-to-face interviews within 1week after delivery.Results A total of 81.4% of partners of case women and 71.8% of partners of control women smoked during the women's peri-conceptional period. The adjusted OR for NTDs associated with partner smoking was 1.6 (95% CI 1.2 to 2.1). Compared with non-smoking women with non-smoking partners, fetal NTD risk among women with smoking partners was 1.7 (1.3 to 2.4) and 1.1 (0.7 to 1.7) for women exposed and not exposed to partner smoking, respectively. Among women who were exposed to partner smoking, the risk of NTDs was 1.4 (0.9 to 2.0), 1.8 (1.2 to 2.6), 1.9 (1.2 to 3.0) and 2.7 (1.6 to 4.7) for partner smoking of