An Exocrine Pancreatic Stress Test with 11C-Acetate PET and Secretin Stimulation
An Exocrine Pancreatic Stress Test with 11C-Acetate PET and Secretin Stimulation
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DOI：
10.2967/jnumed.113.135681
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发表时间：
2014-07-01
影响因子：
9.3
通讯作者：
Wahl, Richard L.
中科院分区：
文献类型：
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作者：
Hyun, Joo O.;Lodge, Martin A.;Wahl, Richard L.
本研究的目的是发展胰腺外分泌功能的无创影像学检查。方法：在这项初步研究中，5名健康志愿者接受了两次60分钟的动态c -11-醋酸酯PET研究，一次在静脉注射分泌素之前，一次在静脉注射后。使用1室模型和图像衍生输入函数对胰腺进行动力学分析。从汇总的图像中，测量胰腺和肝脏的标准化摄取值，并计算胰肝比。结果：所有5名志愿者的基线k(1)和k(2)数据一致。刺激分泌素后，k(1)、k(2)显著升高（配对t检验P = 0.046、P = 0.023）。在汇总的PET图像中，胰肝比降低（P = 0.037）。分泌素刺激后十二指肠c -11-乙酸酯活性增加，与分泌素诱导的分泌一致。结论：c -11-乙酸酯PET研究与分泌素刺激显示出作为评估胰腺外分泌功能的无创方法的潜力。
The purpose of this study was to develop a noninvasive imaging test of pancreatic exocrine function. Methods: In this pilot study, 5 healthy volunteers underwent two 60-min dynamic C-11-acetate PET studies, one before and one after intravenous secretin administration. Kinetic analysis of the pancreas was performed using a 1-compartment model and an image-derived input function. From summed images, standardized uptake values were measured from the pancreas and the liver, and the pancreas-to-liver ratio was computed. Results: The baseline k(1) and k(2) data for all 5 volunteers were consistent. After secretin stimulation, the k(1) and k(2) significantly increased (paired t test P = 0.046 and P = 0.023, respectively). In the summed PET images, the pancreas-to-liver ratio decreased (P = 0.037). Increased C-11-acetate activity was observed in the duodenum after secretin stimulation consistent with secretin-induced secretion. Conclusion: C-11-acetate PET studies with secretin stimulation show potential as a noninvasive method for assessing pancreatic exocrine function.