RELATIVE IMMUNOGENICITY OF THE COLD-ADAPTED INFLUENZA-VIRUS A/ANN/ARBOR/6/60 (A/AA/6/60-CA), RECOMBINANTS OF A/AA/6/60-CA, AND PARENTAL STRAINS WITH SIMILAR SURFACE-ANTIGENS
RELATIVE IMMUNOGENICITY OF THE COLD-ADAPTED INFLUENZA-VIRUS A/ANN/ARBOR/6/60 (A/AA/6/60-CA), RECOMBINANTS OF A/AA/6/60-CA, AND PARENTAL STRAINS WITH SIMILAR SURFACE-ANTIGENS
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DOI：
10.1128/iai.43.2.457-462.1984
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发表时间：
1984-01-01
影响因子：
3.1
通讯作者：
BARRY, RD
中科院分区：
文献类型：
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作者：
TANNOCK, GA;PAUL, JA;BARRY, RD
在CSL小鼠中，几种冷适应（ca）病毒的免疫原性与具有相似表面抗原的野生型亲本病毒的免疫原性进行了比较，根据清除由104.5中位组织培养感染剂量组成的野生型病毒所需要的接种剂量。所有ca病毒的免疫原性都比其野生型亲本株低101.3-103.4倍，这可能是由于ca病毒在小鼠呼吸道复制的能力有限。当两次相当小的剂量间隔3周给药时，它们的免疫原性显著增强。ca病毒两次给药和野生型单次给药的免疫原性因其表面抗原而异。表面抗原为H2N2 A/Ann Arbor/6/60和H3N2 A/Queensland/6/72的病毒感染率最高，表面抗原为H1N1 A/HK/123/77的病毒感染率最低。接种A/Ann Arbor/6/60-ca中位组织培养感染剂量为105.0的2剂，间隔3周，对野生型A/Ann Arbor/6/60亲本病毒、2株异源H3N2株和1株H1N1株产生固体免疫。
The immunogenicity of several cold-adapted (ca) viruses was compared in CSL mice with that of wild-type parental viruses with similar surface antigens, according to the vaccinating dose required to clear a challenge consisting of 104.5 median tissue culture infective doses of the wild-type virus. All ca viruses were less immunogenic than their wild-type parental strains by a factor of 101.3-103.4, probably due to the restricted capacity of ca viruses to replicate in the respiratory tracts of mice. Their immunogenicity was considerably enhanced when 2 quite small doses were administered 3 wk apart. The immunogenicity of ca viruses when administered in 2 doses and wild-type viruses when administered as a single dose varied according to their surface antigens. It was highest for viruses with the H2N2 A/Ann Arbor/6/60 and H3N2 A/Queensland/6/72 surface antigens and lowest for those with H1N1 A/HK/123/77 surface antigens. When 2 doses consisting of 105.0 median tissue culture infective doses of A/Ann Arbor/6/60-ca were administered at an interval of 3 wk, solid immunity was induced against the wild-type A/Ann Arbor/6/60 parental virus, 2 heterologous H3N2 strains, and an H1N1 strain.