Association of the Serotonin Transporter Gene Promoter Region (5-HTTLPR) Polymorphism With Biased Attention for Emotional Stimuli
Association of the Serotonin Transporter Gene Promoter Region (5-HTTLPR) Polymorphism With Biased Attention for Emotional Stimuli
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DOI：
10.1037/a0016198
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发表时间：
2009-08-01
影响因子：
4.6
通讯作者：
McGeary, John E.
中科院分区：
文献类型：
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作者：
Beevers, Christopher G.;Wells, Tony T.;McGeary, John E.
5-羟色胺转运体连接多态区域(5-HTTLPR)的缺失多态与情感障碍的易感性有关，但该基因导致易感性的机制尚不清楚。两项研究考察了5-HTTLPR基因多态与非抑郁成年人对情绪刺激的注意偏向之间的关系。使用情绪刺激的空间线索任务评估了有偏见的注意、注意投入和注意脱离的困难。研究I(N=38)的结果表明，与长等位基因纯合子相比，短5-HTTLPR等位基因携带者较长等位基因携带者更难将注意力从悲伤和快乐的刺激中分离出来。研究2受试者(N=144)进行了5-HTTLPR基因分型，包括5-HTTLPR长等位基因rs25531的单核苷酸多态。与研究1一致的是，与研究1一致，低表达5-HTTLPR纯合子个体(即S和L-G)比高表达5-HTTLPR纯合子个体更难将注意力从悲伤、快乐和恐惧刺激中分离出来。由于这种关联存在于健康的成年人中，它可能是情感障碍的易感因素，在紧张的生活经历中会出现问题。
A deletion polymorphism in the serotonin transporter-linked polymorphic region (5-HTTLPR) has been associated with vulnerability to affective disorders, yet the mechanism by which this gene confers vulnerability remains unclear. Two studies examined associations between the 5-HTTLPR polymorphism and attentional bias for emotional stimuli among nondepressed adults. Biased attention, attention engagement, and difficulty with attention disengagement were assessed with a spatial cuing task using emotional stimuli. Results from Study I (N = 38) indicated that short 5-HTTLPR allele carriers experienced greater difficulty disengaging their attention from sad and happy stimuli compared with long allele homozygotes. Study 2 participants (N = 144) were genotyped for the 5-HTTLPR polymorphism, including single nucleotide polymorphism rs25531 in the long allele of the 5-HTTLPR. Consistent with Study 1, individuals homozygous for the low-expressing 5-HTTLPR alleles (i.e., S and L-G) experienced greater difficulty disengaging attention from sad, happy, and fear stimuli than high-expressing 5-HTTLPR homozygotes. Because this association exists in healthy adults, it may represent a susceptibility factor for affective disorders that becomes problematic during stressful life experiences.