Important Role of Menarche in Development of Estrogen Receptor-Negative Breast Cancer in African American Women
Important Role of Menarche in Development of Estrogen Receptor-Negative Breast Cancer in African American Women
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DOI：
10.1093/jnci/djv172
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发表时间：
2015-09-01
影响因子：
10.3
通讯作者：
Palmer, Julie R.
中科院分区：
文献类型：
--
作者：
Ambrosone, Christine B.;Zirpoli, Gary;Palmer, Julie R.
背景：月经初潮是乳腺细胞分化命运的关键时间点。非裔美国女性的月经初潮年龄较小，这可能与她们患雌激素受体阴性(ER-)乳腺癌的高发生率有关。方法：在琥珀联盟中，使用4426名患有乳腺癌的非裔美国女性和17474名对照的协调数据，我们使用多分类Logistic回归估计了月经初潮和第一次活产年龄的优势比(OR)和95%可信区间(CI)，以及ER+和ER-乳腺癌之间的间隔。所有的统计检验都是双面的。结果：在月经初潮年龄较晚的产妇和未产妇中，ER乳腺癌的风险均降低(>；=15vs
Background: Menarche is a critical time point for diverging fates of mammary cells of origin. African American women have young age at menarche, which could be associated with their high rates of estrogen receptor-negative (ER-) breast cancer.Methods: In the AMBER Consortium, using harmonized data from 4426 African American women with breast cancer and 17 474 controls, we used polytomous logistic regression to estimate odds ratios (ORs) and 95% confidence intervals (CIs) for ages at menarche and first live birth (FLB), and the interval between, in relation to ER+ and ER-breast cancer. All statistical tests were two-sided.Results: Risk of ER-breast cancer was reduced with later age at menarche among both parous and nulliparous women (>= 15 vs