Preparation of chitosan/SiO2-loaded graphene composite beads for efficient removal of bilirubin
Preparation of chitosan/SiO2-loaded graphene composite beads for efficient removal of bilirubin
复制标题
壳聚糖/SiO2负载石墨烯复合珠的制备用于高效去除胆红素
DOI：
10.1016/j.carbon.2018.11.045
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发表时间：
2019-03-01
期刊：
影响因子：
10.9
通讯作者：
Ou, Lailiang
中科院分区：
文献类型：
--
作者：
Chen, Jian;Ma, Yingda;Ou, Lailiang
多孔纳米复合材料具有良好的吸附性能，但纳米填料在聚合物基体中的均匀分散仍是一个具有挑战性的技术难题。在本研究中，通过负载SiO2的改性成功地提高了石墨烯在壳聚糖悬浮液中的分散性。采用相转化法制备了交联壳聚糖/石墨烯（CS/grapheneSiO（2））复合微球。通过扫描电子显微镜和拉曼光谱对所得CS/graphene-SiO2珠进行了表征，这清楚地表明石墨烯在壳聚糖基质中分散良好。吸附结果表明，CS/graphene-SiO2微球对胆红素的吸附率（77.87%）明显高于纯壳聚糖（CS）微球（22.47%），这主要是由于石墨烯的疏水力和CS氨基所提供的静电相互作用之间的协同作用。胆红素的吸附符合单分子层吸附模型和准一级吸附动力学模型。与CS珠相比，由于石墨烯的掺入，复合珠的机械强度显著提高。对溶血活性和血液成分的影响可以忽略不计，这表明所获得的复合珠与血液具有优异的相容性。总体而言，所提出的CS/石墨烯-SiO2珠作为胆红素的有效吸附剂在血液净化应用中具有很高的潜力。(C)2018爱思唯尔有限公司版权所有
Porous nanocomposite materials possess enhanced adsorption properties, but uniformly dispersing nanofillers in polymer matrices is still a challenging technical difficulty. In this study, modification through loading with SiO2 successfully improved the dispersibility of graphene in chitosan suspensions. By employing a phase-inversion method, cross-linked chitosan/SiO2-loaded graphene (CS/grapheneSiO(2)) composite beads were prepared. The resulting CS/graphene-SiO2 beads were characterized by scanning electron microscopy and Raman spectroscopy, which clearly showed that graphene was welldispersed in the chitosan matrix. Adsorption results demonstrated that CS/graphene-SiO2 beads possessed much better adsorption capacity for bilirubin (77.87%) compared to pure chitosan (CS) beads (22.47%), mainly due to the synergistic effect between the hydrophobic forces of graphene and the electrostatic interactions provided by the amino groups of CS. The adsorption of bilirubin was found to match a monolayer model, as well as a pseudo-first-order kinetic model. The mechanical strength of composite beads was significantly improved as compared to CS beads, due to the incorporation of graphene. The effects on hemolytic activity and the components of blood were negligible, which indicate an excellent compatibility of the obtained composite beads with blood. Overall, the proposed CS/graphene-SiO2 beads as an efficient adsorbent for bilirubin have high potential in blood purification applications. (C) 2018 Elsevier Ltd. All rights reserved.