Effect of 8-amino-8-dimethyl-D-araboflavin, 8-amino-8-dimethyl-D-riboflavin and 8-hydroxy-8-demethyl-D-riboflavin on mice.
Effect of 8-amino-8-dimethyl-D-araboflavin, 8-amino-8-dimethyl-D-riboflavin and 8-hydroxy-8-demethyl-D-riboflavin on mice.
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8-氨基-8-二甲基-D-阿拉伯黄素、8-氨基-8-二甲基-D-核黄素和8-羟基-8-去甲基-D-核黄素对小鼠的影响。
DOI：
10.3177/jnsv.20.411
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发表时间：
1974
影响因子：
1.6
通讯作者：
S. Kasai
中科院分区：
文献类型：
--
作者：
K. Matsui;S. Kasai
将含有AAF或ARF而不是RF的饮食给予RF缺陷小鼠，并跟踪生长，9天后取出肝脏和肾脏并称重。实验组和对照组（RF缺陷）之间的生长没有显着差异。AAF可显著增加小鼠肝重/体重，部分小鼠肝脏出现脂肪肝。在肾脏中，实验组和对照组之间的重量百分比和外观没有差异。ARF小鼠的毛发几乎与RF小鼠的毛发一样干净，尽管RF或administered AAF缺乏的小鼠的毛发很脏，看起来像是湿透的。经口或皮下注射给予HF的小鼠在生长、肝脏和肾脏重量以及毛发外观方面与RF缺陷小鼠没有区别。
Diets containing AAF or ARF instead of RF were administered to RF-deficient mice and growth was followed, and after 9 days liver and kidneys were removed and weighed. No significant difference in growth was found between experimental and control (RF-deficient) groups. AAF significantly increased the weight percentage of liver to body weight, and the liver of some mice administered AAF or ARF had the appearance of fatty liver. In kidneys no difference in weight percentage and appearance was found between experimental and control group. The hair of mice administered ARF was nearly as clean as that of mice administered RF, although that of mice deficient in RF or ad-ministered AAF was dirty and had the appearance of being drenched. Mice administered HF per os or by subcutaneous injection were not distinguished from RF-deficient mice in growth, weight of liver and kidneys, and in appearance of hair.