Carcinoma cuniculatum of the oral mucosa: a potentially underdiagnosed entity in the absence of clinical correlation
Carcinoma cuniculatum of the oral mucosa: a potentially underdiagnosed entity in the absence of clinical correlation
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DOI：
10.1016/j.oooo.2014.08.011
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发表时间：
2014-12-01
影响因子：
2.9
通讯作者：
Murrah, Valerie A.
中科院分区：
文献类型：
--
作者：
Padilla, Ricardo J.;Murrah, Valerie A.
Objective.描述楔状体癌（CC）的特征，强调潜在的治疗错误。研究设计。一项回顾性研究调查了CC的档案病例。对临床、显微镜和管理参数进行分析。本文总结了10例病例的临床和显微镜特征。CC显示无柄粉红色/红色轻度乳头状表面。在组织学上，CC呈现一种迂曲的浸润成分，其乳头状外观比疣状癌更微妙。CC是一种不同于疣状癌的鳞状细胞癌的罕见变异。诊断延迟是由于表面样本的误解或缺乏对实体的认识。无细胞学改变和异常结构导致CC诊断不足，与临床病理无关。临床医生应提交多个显示鹅卵石样表面的病变深部样本，并向病理学家提供临床照片。病理学家可以通过彻底的活检取样和根据需要要求额外的组织来避免诊断不足。
Objective. To delineate the features of carcinoma cuniculatum (CC), emphasizing potential management errors.Study Design. A retrospective study examined archival cases of CC. An analysis of clinical, microscopic, and management parameters was performed.Results. Ten cases were identified, and their clinical and microscopic features were summarized. CC exhibits a sessile pink/red mildly papillary surface. Histologically, CC presents a tortuous invasive component with a more subtle papillary appearance than verrucous carcinoma.Conclusions. CC is an uncommon variant of squamous cell carcinoma distinct from verrucous carcinoma. Diagnostic delays result from misinterpretation of superficial samples or lack of awareness of the entity. Bland cytology and unusual architecture result in underdiagnosis of CC without clinicopathologic correlation. Clinicians should submit multiple deep samples of lesions displaying a cobblestone-like surface and provide a clinical photograph to the pathologist. Pathologists can avoid underdiagnosis by thorough sampling of biopsies and requesting additional tissue as needed.