DIABETOGENIC EFFECTS OF CHRONIC ORAL CADMIUM ADMINISTRATION TO NEONATAL RATS
DIABETOGENIC EFFECTS OF CHRONIC ORAL CADMIUM ADMINISTRATION TO NEONATAL RATS
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DOI：
10.1111/j.1476-5381.1980.tb10895.x
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发表时间：
1980-01-01
影响因子：
7.3
通讯作者：
SINGHAL, RL
中科院分区：
文献类型：
--
作者：
MERALI, Z;SINGHAL, RL
1新生大鼠长期口服镉(每天0.1和1.0μg/g，持续45天)破坏了糖平衡，表现为高血糖、肝糖原减少和肝组织糖异生潜能增强。2慢性镉暴露还增加肝组织环磷酸腺苷，并伴随基础、肾上腺素和高血糖素刺激形式的腺苷环化酶(S)升高。3为评价胰岛细胞对葡萄糖的反应性，将对照组和染镉组分离的胰岛置于体外培养，测定胰岛素分泌率。在葡萄糖浓度为0.5 mg/ml时，胰岛素释放速率无显著差异。然而，在较高的葡萄糖浓度(1.5和3.0 mg/ml)下，镉暴露的大鼠胰岛分泌的胰岛素明显低于对照动物。4本文的结果与镉致糖尿病作用的可能机制有关。
1Chronic exposure of neonatal rats to oral cadmium (Cd) (0.1 and 1.0 μg/g daily for 45 days) disturbed glucose homeostasis, as reflected by hyperglycaemia, reduced liver glycogen and enhanced gluconeogenic potential of hepatic tissue.2This Cd‐exposure regimen also increased hepatic cyclic adenosine 3′,5′‐monophosphate (cyclic AMP) which was accompanied by enhancement of basal, adrenaline and glucagon‐stimulated form(s) of adenylate cyclase.3In order to assess the responsiveness of pancreatic beta cells to glucose, islets isolated from control as well as Cd‐exposed animals were incubatedin vitroand their rate of insulin secretion determined. In the presence of glucose 0.5 mg/ml, there was no significant difference in the rate of insulin release. However, at higher glucose concentrations (1.5 and 3.0 mg/ml), the islets from Cd‐exposed rats released significantly less insulin than those of control animals.4The results are discussed in relation to the possible mechanism of the diabetogenic effect of Cd.