Comparison of sucrose and human milk on pain response in newborns
Comparison of sucrose and human milk on pain response in newborns
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蔗糖和母乳对新生儿疼痛反应的比较
DOI：
10.1007/s004310051011
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发表时间：
1999
影响因子：
3.6
通讯作者：
M. Başaran
中科院分区：
文献类型：
--
作者：
R. Örs;E. Özek;G. Baysoy;D. Cebeci;H. Bilgen;M. Türküner;M. Başaran
摘要本研究的目的是比较2 ml 25%蔗糖和母乳对健康足月新生儿的镇痛效果。健康婴儿（n = 102）被随机分配到三种溶液（蔗糖、人乳、无菌水）中的一种，在取足跟刺血样本前2分钟。记录患者在1、2、3 min时的哭闹时间、恢复时间和心率变化百分比的中位数。蔗糖组、安慰剂组和母乳组的中位哭泣时间分别为36、52和62秒（P = 0.0009）。在蔗糖组中，与母乳组和安慰剂组相比，哭泣时间显著减少。同样，蔗糖组的中位恢复时间（72 s）短于母乳组（112 s）和安慰剂组（124 s） （P = 0.004）。蔗糖组在1、2、3 min时的心率百分比变化也显著低于蔗糖组（P = 0.008, P = 0.01, P = 0.002）。
Abstract The aim of this study was to compare the analgesic effect of 2 ml 25% sucrose and human milk in a group of healthy term newborns. Healthy infants (n = 102) were randomly allocated to receive one of three solutions (sucrose, human milk, sterile water) 2 min prior to taking a heel prick blood sample. The median values of crying time, recovery time and percentage change in heart rate at 1, 2 and 3 min were recorded in response to the heel prick. Median crying times were 36, 52, and 62 s in the sucrose, placebo and human milk groups, respectively (P = 0.0009). In the sucrose group, there was a significant reduction in crying time compared to human milk and placebo groups. Similarly, the median recovery time in the sucrose group (72 s) was shorter than that in the human milk (112 s) and placebo groups (124 s) (P = 0.004). The percentage change in heart rate at 1, 2 and 3 min was also significantly lower in the sucrose group (P = 0.008, P = 0.01, P = 0.002 at 1, 2, and 3 min respectively).
Conclusion The orosensorial antinociceptive effect of human milk is not as effective as an analgesic as a 25% sucrose solution.