Modulating neuronal responses by controlled integration of acetylcholine-like functionalities in biomimetic polymers
Modulating neuronal responses by controlled integration of acetylcholine-like functionalities in biomimetic polymers
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DOI：
10.1002/adma.200701747
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发表时间：
2007-12-17
影响因子：
29.4
通讯作者：
Wang, Yadong
中科院分区：
文献类型：
--
作者：
Gumera, Christiane B.;Wang, Yadong
本文介绍了一种神经活性材料的新途径，它依赖于将神经递质类功能基团整合到合成聚合物中。采用模块化设计方法合成了一系列具有不同浓度乙酰胆碱样官能团(ALF)的可生物降解聚合物。ALF含量中等的聚合物在促进轴突萌发和延伸方面类似于层粘连蛋白，同时保持了神经元的表型蛋白表达。
This paper describes a new pathway to neuroactive materials that relies on integration of neurotransmitter-like functional groups into synthetic polymers. A series of biodegradable polymers are synthesized with varying concentrations of acetylcholine-like functionalities (ALFs) using a modular design. The polymers with medium ALF contents resemble laminin in promoting neurite sprouting and extension while maintaining phenotypic protein expression of neurons.[GRAPHICS]