ALZHEIMERS-DISEASE AFFECTS LIMBIC NUCLEI OF THE THALAMUS
ALZHEIMERS-DISEASE AFFECTS LIMBIC NUCLEI OF THE THALAMUS
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DOI：
10.1007/bf00305867
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发表时间：
1991-01-01
影响因子：
12.7
通讯作者：
BRAAK, E
中科院分区：
文献类型：
--
作者：
BRAAK, H;BRAAK, E
本文应用淀粉样蛋白和神经元变化的敏感银技术，观察了阿尔茨海默病丘脑边缘核的病理改变。 几乎所有的丘脑核团都有大量的细胞外淀粉样蛋白沉积。 前腹侧核含有许多大的球状斑块，其他区域含有更密集和更小的沉积物，而第三脑室室管膜衬里下的灰质狭窄区域几乎没有淀粉样蛋白。 神经元内的神经系统的变化，遇到的形式扩张的嗜银过程覆盖内侧凸的前腹核。 类似的结构，虽然在相当小的密度，发生在外侧相邻的网状核。 前核复合体、侧背核、板内复合体部分、室旁核和连合核含有大量神经纤维缠结和神经纤维丝。 前背核受累最重。 乍一看，丘脑似乎只受到阿尔茨海默病的轻微影响。 仔细观察发现，严重的变化仅限于少数边缘核。 在所有研究的严重阿尔茨海默病病例中，这些变化在数量、类型和位置上几乎相同。 据推测，这些变化大大阻碍了信息通过边缘电路的传输。
Sensitive silver techniques for amyloid and neurofibrillary changes were applied to examine the pathological changes revealed by limbic nuclei of the thalamus in Alzheimer's disease. Large numbers of extracellular amyloid deposits occurred in almost all thalamic nuclei. The antero-ventral nucleus harbored numerous large globular patches, other areas contained more densely packed and smaller deposits, while narrow zones of gray matter subjacent to the ependymal lining of the third ventricle remained virtually devoid of amyloid. Intraneuronal neurofibrillary changes were encountered in the form of distended argyrophilic processes covering the medial convexity of the antero-ventral nucleus. Similar structures, although in considerably lesser density, occurred in the laterally adjoining reticular nucleus. The anterior nuclear complex, the latero-dorsal nucleus, portions of the intralaminar complex, the paraventricular and reuniens nucleus contained numerous neurofibrillary tangles and neuropil threads. The antero-dorsal nucleus showed the most severe involvement. At first glance, the thalamus appeared to be only mildly affected by Alzheimer's disease. Closer inspection revealed that severe changes were confined to only a few limbic nuclei. These changes were virtually identical in amount, type and location in all cases of severe Alzheimer's disease studied. It is assumed that these changes considerably hamper the transport of information through limbic circuits.